Comparison of Ondansetron with combination of ondansetron and dexamethasone for prevention of nausea and vomiting after Carboprost in LSCS patients under spinal anesthesia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Introduction : Carboprost is used to prevent and treat postpartum hemorrhage in pregnant patients, however it is associated with severe nausea and vomiting .This is quite discomforting for the patient and the treating obstetrician. This study was designed to compare ondansetron only and ondansetron along with dexamethasone for the prevention of Carboprost induced nausea and vomiting Materials and Methods: This double blinded study Was done at a peripheral hospital from July 2016 to July 2017.200 ASA Class I and II full-term pregnant patients scheduled for elective LSCS were randomly allocated into two groups namely group O and group OD Inj.carboprost 250 mcg was given intramuscularly after the delivery of anterior shoulder in both groups.Inj ondansetron 4 mg and Inj dexamethasone 4mgsIV with ondansetron4mgs was given respectively to both groups. Patients were observed intraoperatively and in the recovery room and ward for any episodes of nausea and vomiting. Rescue antiemetic was given if the patient had PONV score of 2 and was also recorded. Results: The severity of nausea in immediate postoperative period was significantly less in theOD group compared to O group (p value0.0010)The incidence of post op nausea and vomiting is significantly lower in the OD group than in O group 43 (43%) Vs 55 (59%) p value of 0.036 in 0-6 hrs. and also overall in 0-24 hours 59(63%) Vs 45(45%) p value of 0.016. The incidence of rescue antiemetic used was significantly lower in the OD group than in the D group during the 0-6 hours after the operation (13 vs. 24%) (P = 0.043). Incidence of side effects (headache, constipation and dizziness) was comparable in both the groups. Conclusion: We conclude that Combination of Dexamethasone and ondansetron in comparison to ondansetron alone, decreases the overall incidence of carboprost induced nausea and vomiting in the immediate postoperative period
Authors and Affiliations
Roshni Abichandani, Rajat Jain, AK Singh
Keywords
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- EP ID EP262519
- DOI 10.9790/0853-1609107276.
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