Comparison of post-operative ICU sedation between dexmedetomidine and fentanyl in adult patients
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 2
Abstract
Background: Patients on mechanical ventilation in intensive care unit (ICU) are often uncomfortable because of anxiety, pain, and endotracheal intubation. Therefore, require sedation, alpha2 agonists are known to produce sedation. Aims: The present study was undertaken to evaluate the efficacy and safety of dexmedetomidine in comparison to fentanyl in the management of sedation for postoperative intensive care unit (ICU) patients, as a sedative agent. Methods: Total thirty patients of either sex, age between 18-70 years and who were ambulatory and who required the postoperative mechanical ventilation or postoperative sedation were enrolled and divided in two equal groups. Group D received dexmedetomidine and group F received fentanyl. All these patients were treated for the period of 8 to 24 h. Pulse rate, respiratory rate, blood pressure (Systolic/Diastolic), mean arterial pressure and SPO2; Ramsay sedation scale, VAS, recovery time from sedation and analgesic requirement were noted. Results: Pulse rate, respiratory rate and blood pressure were comparable between two groups. Depth of sedation and extubation time were similar. To maintain analgesia throughout the study period, patients receiving fentanyl infusions required significantly more analgesics than patients receiving dexmedetomidine. Conclusions: Dexmedetomidine appears to be a safe and acceptable ICU sedative agent when both the clinician's and patient's perspectives are considered.
Authors and Affiliations
Dr Virendrakumar Belekar
Keywords
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