COMPARISON OF PREDISPOSING FACTORS FOR THE DEVELOPMENT OF DRUG SUSCEPTIBLE AND DRUG RESISTANT PULMONARY TB RE-TREATMENT CASES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 33
Abstract
BACKGROUND At present, multidrug resistant (MDR-TB) is a challenge in global efforts to prevent and control tuberculosis. WHO reports estimate that 3.5% of newly diagnosed TB patients and 20.5% of previously treated patients had MDR-TB.1,2 Known risk factors for emergence of MDR TB include age, sex, number of times exposed to ATT treatment, HIV status and alcoholism. 3,4,5 The aim of the study is to compare the predisposing factors towards the development of drug susceptible and drug resistant PTB among retreatment cases. MATERIALS AND METHODS This study was conducted among 300 retreatment pulmonary tuberculosis patients attending Government Hospital of Thoracic Medicine, Tambaram sanatorium from 2016-18. 150 patients each of drug (Rifampicin) sensitive and drug resistant (Rifampicin) TB diagnosed by CBNAAT were selected by simple random sampling. Detailed data including demographic particulars, treatment history, personal history, HIV status were collected using a standardised questionnaire and the results were statistically analysed. RESULTS Age >45 years, male sex, lower educational status, history of treatment interruption, HIV positive status, smoking and alcoholism were found to have a statistically significant correlation with the development of drug resistant TB. CONCLUSION Several factors contribute to the development of drug resistant tuberculosis. If the goal of eliminating TB by 2025 is to be achieved, the focus should be on the prevention of development of drug resistant TB by ensuring that patients take full course of treatment properly the first time. Knowledge of factors associated with drug resistant TB will help us to plan better intervention strategies such as pretreatment counselling, smoking and alcohol cessation clinic.
Authors and Affiliations
Balaji Ganapathi Kothandapani, Sridhar Rathinam, Vinod Kumar Viswanathan, Kumar Satagopan
Keywords
Related Articles
- EP ID EP571009
- DOI 10.18410/jebmh/2018/502
- Views 97
- Downloads 0
PSYCHIATRIC MORBIDITY AND MARITAL QUALITY AMONG WIVES OF PATIENTS WITH ALCOHOL DEPENDENCE SYNDROME
BACKGROUND: Alcohol Dependence syndrome (ADS) is one of the most common psychiatric disorders that has deleterious consequences not only on the patient with ADS but also hampers social, financial, and legal matters of hi...
CHEST RADIOGRAPH AND HRCT IN CHRONIC LUNG DISEASE
BACKGROUND HRCT uses high spatial resolution of lung parenchyma, using thin collimation, high-spatial frequency reconstruction algorithm and increased kVp and mA settings. Alterations in anatomy can be identified at leve...
OUTCOME OF GROWTH MODULATION USING THE TENSION BAND PRINCIPLE OF 8 PLATE FOR PAEDIATRIC GENU VALGUM DEFORMITY
BACKGROUND Osteotomies have traditionally been the mainstay of treating deformities not only in adults but also in children. Osteotomies involve extensive soft tissue dissection, complications of wound closure, infection...
ANAESTHETIC IMPLICATIONS FOR PARTURIENT WITH GESTATIONAL DIABETES MELLITUS, THYROTOXICOSIS AND HYPERTENSION
The presence of co-morbidities during pregnancy can pose numerous challenges to the attending anesthesiologist during operative deliveries. We describe a case of a parturient who had conceived after five years of married...
COMPARISON OF EFFICACY OF INTRAVENOUS PARACETAMOL AND INTRAVENOUS DICLOFENAC FOR POST-OPERATIVE ANALGESIA IN LAPAROSCOPIC SURGERIES
BACKGROUND This was a double blind, prospective randomized clinical study. 105 patients scheduled to undergo elective laparoscopic surgery in a tertiary hospital between Jan 2014 to Aug 2015 were randomly selected by clo...