Comparison of Salbutamol to Adrenaline Nebulization in Acute Severe Bronchiolitis: An Original Research Paper
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 2
Abstract
Background: The prevalent use of nebulized bronchodilators in bronchiolitis has not proved beneficial. The use of adrenergic drugs has shown some promise. The efficacy of nebulized adrenaline versus salbutamol in bronchiolitis and the safety profile of the two were studied. Materials and Methods: Effects of nebulized adrenaline and salbutamol were compared in children with moderate to severe acute bronchiolitis. 21 infants in the age group of 1 month-1 year were enrolled in the study. Children received salbutamol (0.15 mg/kg with saline to a total of 3 ml) through nebulizer with oxygen or adrenaline 1:10000 (0.5 ml/kg subject to a maximum of 2.5 ml with saline to make it 3 ml) via nebulizer with oxygen. Changes in heart rate, respiratory rate (RR), respiratory distress assessment instrument (RDAI) score, oxygen saturation (SpO2), oxygen requirement, duration of hospital stay, and the side effects were studied. Results: The respiratory status was better with significant improvement in RR, RDAI score and SpO2, decreased oxygen requirement and shorter hospital stay in the adrenaline group. There were no significant side effects in either group. Conclusion: Nebulized adrenaline is a useful and safe drug for moderate/severe bronchiolitis and is superior to salbutamol.
Authors and Affiliations
Gayti Koley, K C Koley
Keywords
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