COMPARISON OF SIGNIFICANCE OF LIPID PROFILE WITH LIVER FUNCTION TESTS IN DENGUE FEVER
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 14
Abstract
BACKGROUND Dengue is the most prevalent mosquito borne viral infection with rapidly changing epidemiology over the last few years. Lipoproteins play a pathophysiological role in the hosts immune response to severe infection. The need to know the lipoprotein status in dengue fever, find its correlation with severity, liver function tests, and clinical outcome are the objectives of this study. METHODS This prospective observational study was taken up involving 50 adults diagnosed with dengue fever between December 2013 to December 2014 in Mysore Medical College. Patients were classified based on severity of dengue fever (DF), dengue haemorrhagic fever (DHF), dengue shock syndrome (DSS). Fasting lipid profile, liver function test (LFT), complete blood count were estimated on day 1 and day 5 of admission. RESULTS The study population comprised of 50 dengue sero positive cases. The total cholesterol was greatly reduced and LFT alterations were seen highest in DSS group. During admission, serum cholesterol and liver enzymes showed statistically significant difference in their mean concentrations in the three groups of dengue infection. The spearman correlation analysis shows that AST and total cholesterol had negative correlation (r= -0.782; p <0.01), whereas ALT and cholesterol also showed similar correlation (r= -0.738; p< 0.01). CONCLUSIONS Total cholesterol, HDL and LDL of dengue fever cases were significantly reduced at admission in comparison to the second estimation on day 5. Mean cholesterol, triglyceride and LDL levels showed statistically significant (p value <0.05) changes with severity of dengue. LFT was correlated with the severity of dengue fever. These abnormal values may serve as indicators for recognizing patients at increased risk for DHF and DSS, thus serving as prognostic markers of the dengue infected individuals.
Authors and Affiliations
Santhosh Santhosh, Indumathi Shankaraiah, Harish Kiran
Keywords
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- EP ID EP557264
- DOI 10.14260/jemds/2019/259
- Views 85
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