Comparison of single loading dose magnesium sulphate regimen with low dose magnesium sulphate regimen in the treatment of eclampsia
Journal Title: Indian Journal of Obstetrics and Gynecology Research - Year 2017, Vol 4, Issue 4
Abstract
Introduction: Eclampsia contributes to maternal mortality in developing, underdeveloped world. Various drugs have been tried to treat eclampsia. Magnesium sulphate has become the drug of choice due to various advantages and is associated with adverse outcome for both mother and fetus if not used correctly. This study was undertaken to know safety, efficacy of reduced doses of Magnesium sulphate as compared to standard dose. Materials and Method: After obtaining institution ethical clearance and written informed consent this study was conducted on 60 subjects for 2 years. Patients diagnosed as eclampsia and presenting with generalized tonic clonic seizure during antenatal, intrapartum, postnatal were included. Group A received single loading dose of magnesium sulphate (4gm (20%) I V over 3-5 min followed by 10gm (50%) deep i.m. (5gm in each buttock)). Group B patients received low dose magnesium sulphate (4gm (20%) i.v. over 3-5 min followed by 6gm (50%) deep i.m. (3 gm in each buttock) and maintenance dose of 3 gm i.m., every 4 hourly in alternate buttock) which was continued 24 hours after last convulsion or delivery whichever is later. Mode of delivery, recurrence of convulsion, maternal and fetal morbidity and mortality were studied. Results: Maternal and foetal outcome was comparable in both the groups. There was no significant difference with regards to recurrence of convulsions. There was no statistically significant increase in incidence of caesarian section in group B compared to group A (p>0.05). Conclusion: Single dose regime controls the eclamptic convulsions with good maternal and neonatal outcome.
Authors and Affiliations
Sunitha HB, Sonam Parikh, Manjushree R Waikar, Vinayak Panchgar, Akshaya N. Shetti
Keywords
Related Articles
- EP ID EP315047
- DOI 10.18231/2394-2754.2017.0075
- Views 69
- Downloads 0
A Non- surgical lifeline for Abnormal uterine bleeding (AUB) - the LNG IUS
Objective: To study effectiveness of LNG IUS (levonorgestrel releasing intrauterine system) insertion for patients with Abnormal uterine bleeding and to assess whether the LNG IUS can provide a conservative alternative t...
Knowledge, attitude, and practices of family planning methods among women of reproductive age attending OPD in tertiary care centre, Lucknow, Uttar Pradesh
Introduction India with 134 billion people is the second most populated country in the world while china is on the top with over 141 billion people Total fertility rate of India is 22 and the current total fertility rate...
Impact of gestational diabetes mellitus on maternal & fetal outcome
Background: Women with GDM are at increased risk for adverse obstetric and perinatal outcome. Hence, it is imperative that an early detection and management of the disease is done to ensure better maternal and fetal outc...
Induction with transcervical foleys versus iv oxytocin for trial of labor after cesarean(TOLAC)
Objectives: To compare efficacy and safety of induction with transcervical Foley’s catheter and low dose intravenous oxytocin for labor induction in a case of previous LSCS. Methods: One hundred women at term gestation w...
A rare case of accidental symphysiotomy (syphysis pubis fracture) during vaginal delivery
A 25 year old female was referred to C. U. Shah Medical College and Hospital on her 1st post-partum day for post partum hemorrhage and associated widening of pubic symphysis 1 hour after delivering a healthy male child w...