Comparison of the Diagnostic Accuracy of the Gamma-Glutamyl-Transpeptidase/Platelet Ratio with Aspartate Aminotransferase-Platelet Ratio Index and Fibrosis-4 Index in Liver Fibrosis in Chronic Hepatitis B
Journal Title: European Archives of Medical Research - Year 2020, Vol 36, Issue 4
Abstract
Objective: The gamma-glutamyl transpeptidase/platelet ratio (GPR) is a newly developed non-invasive serum marker of significant fibrosis and cirrhosis in patients with chronic hepatitis B (CHB) in West Africa. This study aimed to compare the diagnostic accuracy of the GPR with the aspartate aminotransferase-platelet ratio index (APRI) and with the fibrosis-4 (FIB-4) index for detecting liver fibrosis in Turkish patients with CHB. Methods: Seventy-nine patients with CHB who had undergone liver biopsy were included, and GPR, APRI, and FIB-4 data were obtained. The receiver operating characteristic (ROC) curves and area under the ROC curves (AUROCs) were compared. Results: As regards the fibrosis stages of 79 patients, 5 were F0 (6.3%), 17 were F1 (21.5%), 23 were F2 (29.1%), 23 were F3 (29.1%), and 11 were F4 (13.9%). The AUROCs of the GPR and APRI were similar in the diagnosis of significant fibrosis (0.70 vs. 0.69; p=0.928), advanced fibrosis (0.80 vs. 0.72; p=0.174), and cirrhosis (0.73 vs. 0.75; p=0.771) groups. The AUROCs of the GPR and FIB-4 index were similar for diagnosing significant fibrosis (0.70 vs. 0.79; p=0.090) and advanced fibrosis (0.80 vs. 0.77; p=0.569). However, the AUROCs of the FIB-4 index for diagnosing cirrhosis was significantly higher than those for the GPR (0.73 vs. 0.90; p=0.024) and APRI (0.75 vs. 0.90; p=0.024). Conclusion: The GPR can be used to detect significant fibrosis, advanced fibrosis, and cirrhosis, but was not superior to the APRI or FIB-4 index. FIB-4 index performed better than the GPR and APRI for diagnosing cirrhosis.
Authors and Affiliations
Deniz Öğütmen Koç, Yasemin Gökden
Keywords
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- EP ID EP693339
- DOI 10.4274/eamr.galenos.2020.30592
- Views 60
- Downloads 0
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