Comparison of the effects of gonadotropin-releasing hormone and raloxifeneon the size of uterine leiomyoma
Journal Title: Chronic Diseases Journal - Year 2014, Vol 2, Issue 1
Abstract
BACKGROUND: Uterine leiomyoma is a prevalent benign tumor. Several studies have shown the positive effects of raloxifene in the treatment of leiomyomas. Since raloxifene has fewer side effects than the gonadotropin-releasing hormone (GnRH) agonist, if proven effective, it can be applied easily. This study aimed to compare the medical effects of raloxifene and GnRH on uterine leiomyoma size. METHODS: This clinical trial included 53 women with uterine leiomyoma. Participants were randomly divided into 2 groups of raloxifene and GnRH. The GnRH group received 1 dose per month (intramuscular injection) and the raloxifene group received 60 mg raloxifene orally/day for 3 months. The size of the leiomyoma, prior and during the intervention, was determined by a sonographist. During the study, repeated measurement was used for comparing the trend of alterations in the tumor size. RESULTS: Analysis of changes in leiomyoma tumor size (log of tumor size) by repeated measurement showed that decrease in tumor size in the raloxifene group was significantly higher than GnRH group (P = 0.042). The trends of changes in endometrial thickness were different in the 2 groups and the reduction of thickness was more significant in the GnRH group (P = 0.026). CONCLUSION: This study showed that raloxifene is an appropriate medicine to reduce the size of uterine leiomyoma and is more effective than GnRH.
Authors and Affiliations
Farnaz Zandvakili, Fariba Seyedoshohadaie, Masoumeh Rezaiee, Nasrin Soofizade, Ebrahim Ghaderi
Keywords
Related Articles
- EP ID EP284976
- DOI -
- Views 105
- Downloads 0
The effectiveness of hypnotherapy with physiotherapy: pain intensity, functional disability, and psychological distress among patients with non-specific low back pain
BACKGROUND: It has been demonstrated in previous investigations that non-specific low back pain is caused by multiple factors. Evidently, integrative therapies should be used in order to improve this disorder. Documents...
The prevalence of infertility and related factors in patients referred to infertility center in Besat hospital, Sanandaj, Iran
BACKGROUND: Infertility is considered as a prominent health care issue. The present study aimed to determine the prevalence rate of infertility and certain factors relevant to it. METHODS: The current study was performe...
The relationship between the manners of parenting by parents and the extent of anxiety among the students
BACKGROUND: Mental health among the children and adolescents is an essential part of public welfare and health. The transfer of values and culture, and children health are made via training. According to conducted studie...
Fibrosing mediastinitis: An unusual cause of superior vena cava symptoms
Fibrosing mediastinitis is a rare benign disorder caused by the proliferation of acellular collagen and fibrous tissue within the mediastinum. Although many cases are idiopathic, many (and perhaps most) cases are thought...
Importance of patient education in management of chronic diseases
-