Comparison of the efficacy and safety of 2 different antiretroviral regimens in tertiary care hospital: A retrospective observational study
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 3
Abstract
Background: Highly active retroviral therapy has reduced the morbidity and mortality of HIV infection. Although many regimens have reduced the plasma virus load in patients, there are many cases of long-term toxicity, adverse effects, and drug resistance. Aims and Objective: To compare the efficacy and safety between combination of stavudine lamivudine nevirapine (SLN) and stavudine lamivudine efavirenz (SLE) (antiretroviral regimens) in tertiary care hospital. Materials and Methods: A retrospective cohort study was conducted in the anti-retroviral therapy (ART) center of CG Hospital, a tertiary care center at Davangere. Data were collected for the duration of 12 months (June 2012 to May 2013). The study was conducted after obtaining the permission from the institutional ethical committee and incharge officer. Prescriptions of the patients were collected, and relevant information was entered in the preformed pro forma and analyzed. Results: In total of 144 cases, 94 patients received combination therapy of SLN whereas 50 patients received combination therapy of SLE. To compare the baseline parameters such as CD4 counts, weight and hemoglobin with post-treatment values Dunn’s multiple comparison test was applied. To compare the changes in the parameters between the 2 therapies unpaired t-test was applied. There was a statistically significant improvement in CD4 counts in both the therapies but between group comparisons showed no statistical difference, inspite of clinical improvement more pronounced in patients receiving SLN combination. Hemoglobin levels have improved significantly post therapy in both the groups. Conclusion: In this study, there was clinically significant improvement in all the parameters considered for analyses in patients receiving SLN compared to SLE therapy but fails to show statistical significance.
Authors and Affiliations
Reshma S R, Vaneeth Agarwal, Narendranath Sanji, Dinakar KR, Keerthisagar J, Mangala Gowri S R, Navin Patil
Keywords
Related Articles
- EP ID EP289225
- DOI 10.5455/njppp.2017.7.1131318112016
- Views 60
- Downloads 0
Gender-based variations in academic performance of MBBS students of different blood groups
Background: Blood group has been observed to associate differentially with personality and character traits, emotional intelligence and occurrence as well as pathogenesis of various diseases. Academic performance remains...
Effect of abdominal obesity on migraine features in Indian population
Background: Migraine is a common headache disorder affecting large population globally. Some studies found an association between abdominal obesity (AO) and characteristics of migraine headache, whereas others found no s...
The antibacterial activity of contact lens solutions against microbial keratitis
Background: Contact lens has a growing popularity among people with vision impairment as well as for cosmetic reasons. However, its contamination can cause microbial keratitis. This study aimed to test the effectiveness...
Altered taste threshold in chronic Type 2 diabetes mellitus
Background: “Taste” is one of our basic senses. The prevalence of hypogeusia or ageusia is much more than what we are aware of, and hence it is addressed to a lesser extent. Diabetes mellitus (DM) is one such disease, wh...
Effectiveness of relaxation therapy on psychological variables among the elderly in old-age homes - A pilot study
Background: Aging is an inevitable developmental phenomenon even with best nutrition and health care. Consequently, changes occur in the physical, psychological, hormonal, and social realms besides others. The mental dis...