Comparison of Three Different Tests for Diagnosis of Enteric Fever
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 5, Issue 12
Abstract
Background: Enteric fever is a systemic illness caused by Salmonella Typhi and Salmonella Paratyphi. The different methods for diagnosis of enteric fever are blood, bone marrow, rarely stool and urine culture, nucleic acid detection, antibody detection by Widal test, and other rapid diagnostic tests. Aim: The study was performed to evaluate the performance of tube Widal test, Typhiwell enzyme-linked immunosorbent assay (ELISA) test, and Typhifast, an immunochromatographic (ICT) test. Materials and Methods: This study was carried out in the Department of Microbiology in a tertiary care center for 1 year (January–December 2015). The serum samples were collected from the patients with fever who had positive blood culture report. A total of 50 samples were included, of which 21 were positive for S. Typhi, 9 were positive for S. Paratyphi A, and 20 samples were positive for other organisms such as Escherichia coli (8 isolate), Klebsiella pneumoniae (8 isolate), and Staphylococcus aureus (4 isolate) by blood culture. The serum samples were used for doing the various tests for diagnosis of enteric fever such as tube Widal test, Typhiwell, ELISA test, and Typhifast, an ICT test. Results: The three serological tests were performed and compared with blood culture, and it was found that Typhifast had a sensitivity of 70% and specificity of 100%, Typhiwell had a sensitivity of 90% and specificity of 75%, and Widal test had a sensitivity of 83.3% and specificity of 80%. Conclusion: Widal test had a fairly good sensitivity and specificity, whereas Typhifast had a very good specificity but a lower sensitivity.
Authors and Affiliations
Mallika Sengupta, Manideepa Sengupta
Keywords
Related Articles
- EP ID EP478019
- DOI -
- Views 113
- Downloads 0
Awareness and Attitude of Parents toward Avulsed Permanent Tooth of their Children and its Emergency Management in Jammu Population
Aim: The aim of the present study is to determine the awareness and attitude of parents toward avulsed permanent tooth of their children and its emergency management in Jammu population. Materials and Methods: A total of...
Prevalence of Cutaneous Manifestations in Patients with Diabetes Mellitus of North Kerala
Background: Diabetes mellitus (DM) is the most common endocrinal disease which frequently has skin manifestations. The binding of a glucose molecule to the tissue protein results in an effect on structure and function of...
Biophysical Scoring of the Endometrium and Intrauterine Insemination Outcome in the Patient with Infertility
Introduction: Infertility is a condition affecting the couple at its ground level – ability to reproduce. Apart from medical and social consequences, it is also having psychological consequences having spectrum of manife...
Endodontic Management of Single-rooted Mandibular Canine with Two Canals: A Case Series
The mandibular canine usually presents one root with a single large canal located centrally. The possible anatomical variation is the existence of a single root with two canals. The incidence of mandibular single-rooted...
Analytical Study of Occult Spinal Dysraphism - Its Varied Presentations, Management and Outcome in South Indian Population
Abstract Introduction: Occult spinal dysraphism (OSD) represents a subset of spinal dysraphism in which the congenital defects are covered by intact skin. The risk of neurologic deterioration exists at all ages and incre...