Comparison the Pain Relief of Amitriptyline Mouthwash with Benzydamine in Oral Mucositis
Journal Title: Journal of Dentistry, Shiraz University of Medical Sciences - Year 2018, Vol 19, Issue 1
Abstract
Statement of the Problem: A significant proportion of patients undergoing chemotherapy or radiotherapy suffer from mucositis. The first symptom of oral mucositis is pain. Severe pain, burning sensation, and discomfort in the oral cavity make it difficult to continue treatment and even continue living in these patients. Purpose: The aim of this study was to evaluate and compare the effect of amitriptyline mouthwash (in two forms of simple and niosomal) as a local anesthetic agent with benzydamine HCl mouthwash in oral mucositis after radiotherapy or chemotherapy. Materials and Method: This double-blind study was performed on 60 patients with oral mucositis caused by radiotherapy and chemotherapy. The severity of mucositis was determined based on patient judgment; then dental examination was performed and recorded in a checklist. Three groups were assigned based on using either benzydamine HCL, amitriptyline, or niosomal form of amitriptyline. Pain and burning sensation were evaluated with VAS at different time intervals: before use and one, five, ten, and thirty minutes and one hour after using mouthwash. T-test was used to compare the intensity of pain between the two groups. ANOVA and Tukey test were used to compare the intensity of pain between groups. Results: Statistical analyses showed the maximum reduction in pain intensity at two different time intervals (p= 0.04). Ten minutes after the use of niosomal form of amitriptyline, a 95% decrease in pain was observed. A 99% reduction in pain occurred after the use of simple form of amitriptyline (p= 0.04). Conclusion: Use of amitriptyline mouthwash had local anesthetic effects in oral mucositis without systemic side effects. Decrease in the severity of pain with the use of amitriptyline mouthwash was more than that of benzydamine HCL mouthwash.
Authors and Affiliations
Shahla Kakoei, Abbas Pardakhty, Maryam-Al-Sadat Hashemipour, Hasan Larizadeh, Behjat Kalantari, Elaheh Tahmasebi
Keywords
Related Articles
- EP ID EP303079
- DOI -
- Views 100
- Downloads 0
Comparison of the Marginal Bone Loss in One-stage versus Two-stage Implant Surgery
Statement of the Problem: Dental implant is one of the best choices for reconstruction of aesthetic and function. High success rate of these treatments are related to some considerations such as case selection, implant s...
A Rare Condition of Bimaxillary Primary Molar Taurodontism
Taurodontism is a relatively rare variance with a very low incidence in primary dentition and only a few cases have been reported in the literature. It stands a challenge when these teeth require pulp therapy. This case...
Tensile Bond Strength of Three Custom-made Tooth-Colored Implant Superstructures to Titanium Inserts
Statement of the Problem: Hybrid abutments are made of a titanium implant insert and a ceramic component. The tensile bond strength between the titanium implant insert and the ceramic component is not still clearly known...
Effect of 940nm Diode Laser Irradiation on Microtensile Bond Strength of an Etch and Rinse Adhesive (Single Bond 2) to Dentin
Statement of the Problem: Laser can influence bonding mechanism by increasing the penetration depth of adhesive in smear layer. The effect of 940 nm diode laser on microtensile bond strength of adhesive to dentin has not...
Influence of Age on Perception of Best Esthetical Profile
Statement of the Problem: As an important determinant of social acceptability, facial attractiveness can be influenced by decisions of orthodontists through treatment. The perception of facial attractiveness is influence...