Comparitative In-Vitro and Ex-Vivo Evaluation Studies of Natural Polymers on Bioadhesive Clarithromycin Tablets.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 6
Abstract
The present investigation was to formulate controlled release of muco adhesive tablets of clarithromycin followed by it’s evaluation studies. The tablets were formulated by using clarithromycin as drug, used for the treatment of H.pylori infection in peptic ulcer. The natural polysaccharides like, Tamarind Seed Polysaccharide (TSP),obtained from Tamarindus indica and chitosan were used as polymer material for controlled drug release. The formulated tablets of such different polymer were compared for different evaluation studies. The pre formulation studies were performed by using FTIR, DSC studies. The tablets were evaluated for in-process,in-vitro studies. The bioadhesive strength of tablets and polymers were comparatively determined by ex-vivo methods. The selected formulation were subjected to stability studies, the study concluded that Tamarind polysaccharide loaded tablets are more adhesive than chitosan loaded tablets. TSP is the best natural polymer for mucoadhesive due to biodegradability and controlled release mechanism.
Authors and Affiliations
Nishad K. M.
Keywords
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