Comparitative In-Vitro and Ex-Vivo Evaluation Studies of Natural Polymers on Bioadhesive Clarithromycin Tablets.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 6
Abstract
The present investigation was to formulate controlled release of muco adhesive tablets of clarithromycin followed by it’s evaluation studies. The tablets were formulated by using clarithromycin as drug, used for the treatment of H.pylori infection in peptic ulcer. The natural polysaccharides like, Tamarind Seed Polysaccharide (TSP),obtained from Tamarindus indica and chitosan were used as polymer material for controlled drug release. The formulated tablets of such different polymer were compared for different evaluation studies. The pre formulation studies were performed by using FTIR, DSC studies. The tablets were evaluated for in-process,in-vitro studies. The bioadhesive strength of tablets and polymers were comparatively determined by ex-vivo methods. The selected formulation were subjected to stability studies, the study concluded that Tamarind polysaccharide loaded tablets are more adhesive than chitosan loaded tablets. TSP is the best natural polymer for mucoadhesive due to biodegradability and controlled release mechanism.
Authors and Affiliations
Nishad K. M.
Keywords
Related Articles
- EP ID EP531372
- DOI -
- Views 111
- Downloads 0
Atherosclerosis: Its Affinity For Different Coronary Arteries And Their Sites
Background-Atherosclerosis of coronary arteries is a common phenomenon seen to be prevalent worldwide. Methods-This was observational type of analytical study. A consecutive series of 100 adult patients having mean age r...
Developing and Validating Modules for Communication Skills for MBBS Students
Introduction: Communication with a patient is the basic art that a doctor has to inculcate. Certain etiquettes have to be followed and discernible speaking skills have to be achieved. Introducing specific programs at the...
Methicillin-Resistant Staphylococcus Aureus Clinico Microbiological correlation in a Tertiary care center in Kerala, India
Methicillin resistant Staphylococcus aureus (MRSA) has emerged as one of the most important nosocomial pathogen to cause severe morbidity and mortality world over. However improper sample collection or increased coloniza...
A Study of Clinical and Laboratory Profile in Septicemic Patients in Tertiary Care Hospital
Introduction: Sepsis is the most frequently encountered medical condition in the intensive care setting and the most common cause of death among hospitalized patients in non-cardiac intensive care units (ICUs), which is...
Impact of Human Colostrum Associated Microbial Population on Neonatal Health
The first thick milk formed immediately after the delivery of newborns by memory glands of female mammals (including humans) is called colostrum. It is the basic primary requirement for the nourishment of newborns. It is...