COMPLEMENT PROTEINS (C1EST, C4, C6), CIRCULATING IMMUNE COMPLEXES AND THE REPEATED BOUT EFFECT
Journal Title: Human Movement - Year 2011, Vol 12, Issue 1
Abstract
Purpose. To determine if the complement system is activated following strenuous eccentrically-biased exercise. Secondly, to determine if complement activation is attenuated (repeated bout effect) following a second bout of the same exercise. Basic procedures. Healthy, active but untrained males performed 2 × 60 min bouts of downhill running, 14 days apart. Samples were taken pre, immediately post (IP), then every hour for twelve hours, and at 24, 48, 72, 96, 120 and 144 h post exercise. Concentrations of C1est, C4, and circulating immune complexes (CIC’s) were determined using standardised nephelometery. C6 was determined using radial immunodifusion. The variables were analysed using a repeated measures ANOVA, with significance set at p < 0.05. Main findings. A significant ( p < 0.01) run effect was observed for C1est, C4, C6 and CIC’s with the concentrations elevated after run 2 compared with run 1. C1est and C4 exhibited significant time effects ( p < 0.001). Conclusions. The complement system is activated following a strenuous bout of downhill running. Complement proteins and circulating immune complexes do not exhibit the same traditional ‘repeated bout effect’ as many other common markers of muscle damage/inflammation. The increase in complement proteins following the second bout may indicate enhanced innate immune function and/or an amplification of the immune response to tissue damage through interaction with the adaptive immune system.
Authors and Affiliations
Stuart J. Semple, Andrew J. McKune, Lucille L. Smith, Barbara Mokgethwa, Ahmed A. Wadee
Keywords
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- EP ID EP103197
- DOI doi: 10.2478/v10038-010-0026-y
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