COMPLEX ANALYSIS OF HEMATOLOGICAL INDICATORS OF PATIENTS WITH COVID-19
Journal Title: Biota. Human. Technology - Year 2024, Vol 1, Issue 2
Abstract
Purpose of the work. To reveal the values of hematological parameters that indicate “typical” and “atypical” immune responses of the human body to the effect of the SARS-CoV-2 virus. Methodology. The research is based on the results of laboratory diagnostics conducted on the basis of the automatic hematology analyzer VS-6000 MINDRAY on the basis of the Municipal Enterprise “Olexandriv Clinical Hospital of the City of Kyiv” for the control group and the research group -patients for whom clinically established the diagnosis "Covid-19, medium degree of severity". Scientific novelty. The substantiation of biochemical processes that reflect the immune response of the human body to the action of the SARS-CoV-2 virus, which causes the coronavirus disease Covid-19, has gained further development. Conclusions. Among the biological markers of the “typical immune response” of the body of patients with Covid-19, the following were selected: an increase compared to the reference values in the level of WBC leukocytes (leukocytosis), GRA granulocytes, a decrease in the level of LYM lymphocytes (lymphopenia), accompanied by neutrophilia. Based on the obtained results, a conditional “risk group” was identified among the members of the research group, for whom doctors clinically diagnosed “Covid-19, medium degree of severity”, have an “atypical immune response” of the body to the effect of the SARS-CoV-2 virus: the levels of WBC leukocytes, LYM lymphocytes, and GRA granulocytes were mainly within the reference values or close to the lower limit ofthe reference values. Additional biological markers were identified that indicate the body's “atypical immune response” to the Covid-19 coronavirus infection: the same level of concentration of lymphocytes (LYM) and neutrophils on the WBC leukocyte histogram; a decrease compared to the reference values of the average volume of erythrocytes (MCV) and the average content of hemoglobin in an erythrocyte (MCH), which causes the occurrence of microcytosis, is the basis for the appearance of anemia; expansion ofthe erythrocyte curve on the RBC histogram, the existence of two peaks indicate heterogeneity of erythrocyte sizes, which causes changes in iron homeostasis and disruption of erythropoiesis; a decrease in the level of thrombocrit (PCT) indicates a high probability of thrombocytopenia; the presence of small “jagged peaks” on the PLT platelet histogram, which does not end at the baseline, indicates the possible aggregation of platelets and their ability to form blood clots.
Authors and Affiliations
Yuliia Ivanytska
Keywords
Related Articles
- EP ID EP753585
- DOI https://doi.org/10.58407/bht.2.24.10
- Views 9
- Downloads 0
ANALYSIS OF TYPES OF SUGAR AND EXPANSION OF ITS RANGE IN UKRAINE
Sugar is important for human life. By consuming sugar, the human body receives a third of the energy for normal metabolism. Sugar is a strategically important product because it is a raw material for the p...
PHENOTYPIC PLASTICITY ТRIFOLIUM REPENS L. AS AN INFORMATIVE INDICATOR SIGN OF ECOPHYTOMONITORING
Purpose of the work. Comparative analysis of intra-and interpopulation variability of Trifolium repens L. by the pattern of a «grey»spot on the leaf of plants in different environmental conditions. Methodology. The resea...
METAL NANOPARTICLES AND ANTIBIOTICS: VALORIZATION OF SYNERGISTIC INTERACTION AND APPLICATION PROSPECTS
Antibiotic resistance has become a global problem arising from the evolutionary adaptation mechanisms of microorganisms.As a result, there is a constant need to find new solutions, such as developing new dru...
THE SPRUCE FORESTS OF THE EASTERN POLESIE DNIEPER PART UNDER A CHANGING CLIMATE
Purpose of the work. Establishing the structure, composition and dynamics of spruce communities in the Dnieper part of Eastern Polesie under the influence of anthropogenic pressure under conditions of climate change. Met...
RED CELL INDICES IN MEN AND WOMEN WITH NORMAL AND LOW PLASMA IRON LEVELS
The aim of this study was to analyze changes in morphological blood parameters in women and men with reduced and normal iron levels. In this study, morphological blood parameters such as the count of red...