Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT
Journal Title: Medical Science and Discovery - Year 2014, Vol 1, Issue 3
Abstract
Objective: Boron neutron capture therapy (BNCT) is an intensive research area for cancer researchers. Especially the side effects and inabilities of conventional therapies in some cases, directs researchers to find out a new cancer therapy methods such as BNCT. One of three important problem of BNCT is targeting of boron to tumor tissue. Borono Phenyl Alanine (BPA) and Borono Sodium Borocaptate (BSH) are already using in clinical studies as boron carriers. New boron carriers are searching for high yield boron accumulation in the tumor tissue. Methods: In this study, a novel 10B carrier was synthesized, ((2R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid ( 10B-DG), for BNCT studies. 10Boric Acid and 2-Deoxy-d-Glucose was complexed ( 10B-DG) through a low-high pH reaction and yield of complexion was tested with FTIR ATR and Liquid Chromatography Mass Spectrometry (LC/MS). Results: Confirmation studies have been carried out by HPLC and chromatograms have confirmed that Borono-2-Deoxy-d-Glucose synthesized with % 80 yield. Conclusions: This compound appears to be an alternative boron carrier for BNCT applications
Authors and Affiliations
Zafer Akan, Hasan Demiroglu, Ugur Avcibasi, Gokhan Oto, Hulya Ozdemir, Sabahattin Deniz, Ali Sadi Basak
Keywords
Related Articles
- EP ID EP520338
- DOI -
- Views 26
- Downloads 0
Compensation of MRI findings in asymptomatic patients with chronic low back pain
Objective: Chronic low back pain can originate from a number of constructs. It has a range of pathologies depending on multifactorial causes. In this study, we aimed to investigate in asymptomatic patients who...
Fine needle aspiration cytology (FNAC) of cystic soft tissue lesions and end tissue metamorphosis-a three year study
Objective: Superficial soft-tissue masses may be seen in clinical practice, but a systematic approach may help to achieve a definitive diagnosis or differential diagnosis for soft tissue lesions. The cystic lesions const...
Effects of aminoguanidine treatment on endothelial nitric oxide synthase expression and nitric oxide levels in streptozotocin induced diabetic rats
Objective: Formation of advanced glycation end products (AGE) in Diabetes Mellitus contribute to endothelial dysfunction by permanent modifications of proteins and decrease NO concentration which regulate vascular tonici...
Effect of extremely low frequency electromagnetic fields on a-Lactalbumin and Sulindac treated colon cancer cells: ELF-EMF and colon cancer
Aim: In this research, we aimed to investigate the effects extremely low frequency electromagnetic fields (ELF-EMF) on proliferation and apoptosis during treatment of primary and metastatic colon cancer cell lines. Mater...
Hyperemesis gravidarum, socio-cultural factors and maternal short psychiatric status
Objective: This study sought to investigate the associations between Hyperemesis Gravidarum and both sociocultural factors and psychiatric status.Material and Methods: A prospective non-randomized cohort design was emplo...