Computational study of the molecular mechanism of Lonicera japonica organic acids against influenza

Journal Title: Traditional Medicine Research - Year 2016, Vol 1, Issue 3

Abstract

1. Molecular docking was applied for determining the potential targets of Lonicera japonica organic acids. 2. Finding relationships between the organic acids and proteins of influenza virus NA, HA, M2 and PB2. 3. Lonicera japonica against influenza virus by multiple components with synergistic effect. 4. Provided molecular evidences on treatment of influenza virus infection with Lonicera japonica and a modern theory for anti-influenza virus treatment by natural herbs. Objective: High evolutionary rate by mutation or by re-assortment makes influenza virus a threat to human health. Recently, many studies have shown that herbal medicine Lonicera japonica is effective against influenza virus infection. However, owing to the natural herb’s complexity in both components and functions, its molecular mechanism is not fully understood. Here, we use computational methods to study the molecular mechanism of anti-influenza activity of organic acids in Lonicera japonica. Methods: Molecular docking was applied for determining the potential targets of the organic acids. Moreover, the compound-target networks were constructed to clarify the relationship between organic acids and their relative targets. Results: Each compound had inhibitory activity against all tested targets. In addition, three molecules (D, E and F) from Lonicera japonica were predicted as potential inhibitors of the mutants of N1 and N9 subtypes of influenza viruses. Conclusions: Our study provided molecular evidences on treatment of influenza virus infection with Lonicera japonica and a modern theory for anti-influenza virus treatment by natural herbs. We confirmed that Lonicera japonica acts synergistically with multiple components against influenza virus. Three molecules (D, E, and F) were selected and predicted as potential inhibitors of N1 and N9 as well as their mutants.

Authors and Affiliations

Luo Xuan, Shen Xia, Hu Ben-Xiang, Wang Hao, Zhao Zhen-Yu, Guo Zi-Hu

Keywords

Related Articles

Reliability and validity of the Tibetan medicine constitution scale: a cross-sectional study of the general population in Beijing, China

Background: The constitutional theory is an important aspect of Tibetan medicine, however a quantitative measurement tool for constitution identification still does not exist. The objective of this study is to evaluate t...

Effects of Da-Cheng-Qi decoction on enteroparalysis and serum inflammatory cytokines in patients with severe acute pancreatitis

Objective: The objective of this study was to investigate the effects of Da-Cheng-Qi decoction (DCQD) on enteroparalysis and levels of the serum inflammatory cytokines C-C motif chemokine ligand 2 (CCL2) and interleukin-...

Challenges and opportunities of applying P4 medicine and traditional Chinese medicine for cancer treatment and prevention in the 21st century: A medical oncologist’s perspectives

Being one of the deadliest diseases, cancer needs a stronger dose of P4 medicine (Predictive, Preventive, Personalized and Participatory) first proposed by Dr. Hood and TCM intervention, as cancer treatment still largely...

A systematical review of traditional Ayurvedic and morden medical perspectives on Ghrita (clarified butter): a boon or bane

Highlights Ghrita (clarified butter), treated as the culprit of a number of diseases, has been depicted incorrectly for a long time. This review presents the complete picture in view of Ayurvedic perspective and recen...

Uncertainty profile for NIR analysis of tanshinone I content in tanshinone extract powders

A rapid, non-destructive and reliable NIR method was developed and validated for the quantification of tanshinone I content in Salvia miltiorrhiza extract. After spectral pretreatment, different variable selection method...

Download PDF file
  • EP ID EP45288
  • DOI 10.12032/TMR201603018
  • Views 284
  • Downloads 0

How To Cite

Luo Xuan, Shen Xia, Hu Ben-Xiang, Wang Hao, Zhao Zhen-Yu, Guo Zi-Hu (2016). Computational study of the molecular mechanism of Lonicera japonica organic acids against influenza. Traditional Medicine Research, 1(3), -. https://europub.co.uk/articles/-A-45288