Concomitant occurrence of Hodgkin variant of Richter syndrome and a lung cancer in a patient with CLL – a case report and review of the literature
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 9
Abstract
Chronic lymphocytic leukaemia (CLL) is usually stable over months to years however a small proportion of cases may transform to more aggressive types of lymphomas. Development of systemic symptoms such as losing weight, fever or local symptoms such as rapidly growing organomegaly in a patient with CLL suggests transformation to high grade lymphoma known as Richter’s syndrome. Similar symptoms can occur in case of second malignancy, which incidence in patients with CLL is 10-20% higher compared to normal population. Here we present a clinical course, diagnostic and therapeutic difficulties in 59-year old patient who simultaneously developed non small cell lung cancer and transformation to Hodgkin lymphoma (HL) 2 years after the diagnosis of CLL. The epidemiology and clinical course of Hodgkin variant of Richter syndrome as well the genetic aberrations possibly shared in development of CLL and lung cancer have been discussed.
Authors and Affiliations
Krzysztof Adamowicz, Wanda Knopińska-Posłuszny, Jan Zaucha
Keywords
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