Concomitant use of tramadol and venlafaxine - evaluation of antidepressant-like activity and other behavioral effects in rats.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
The aim of this study was to evaluate antidepressant-like effect (Porsolt test), locomotor activity and motor coordination of joint administration of tramadol (TRM) and venlafaxine (VEN) in rats.
Authors and Affiliations
Danuta Szkutnik-Fiedler, Krzysztof Kus, Monika Balcerkiewicz, Edmund Grześkowiak, Elżbieta Nowakowska, Kinga Burda, Piotr Ratajczak, Czesław Sadowski
Professor Ullrich Trendelenburg, M.D., Ph.D. (1922–2006). Obituary.
Investigation of the acute effect of leptin on the inhibition of glycogen catabolism by insulin in rat liver perfused in situ.
Leptin, a cytokine secreted by adipose tissue, has been implicated in the insulin resistance associated with obesity. Here we examined the acute influence of leptin at physiological (10 ng/ml) and supraphysiological (50...
Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats.
Previous studies have indicated a role of serotonin (5-HT)2 receptors in modulation of the behavioral effects of cocaine. In the present study, the efficacy of SR 46349B (a 5-HT(2A) receptor antagonist) or SDZ SER-082 (a...
Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type.
Alzheimer's disease (AD) is the most common type of dementia disorder of elderly affecting millions of people. The pathophysiology of the disease is complex and involves multiple pathways of neuronal damage. Sporadic dem...
Association of the MDR1 (ABCB1) gene 3435C>T polymorphism with male infertility.
Infertility is a common problem affecting one in six couples, and in 30% of infertile couples, the male factor is a major cause due to defective sperm quality. P-glycoprotein (P-gp), a product of the MDR1 (ABCB1) gene, m...