Congenital nephrotic syndrome associated with congenital cytomegalovirus infection
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 11
Abstract
Congenital nephrotic syndrome (CNS) is a rare disorder characterized by heavy proteinuria, hypoalbuminaemia and oedema in first 3 months of life. The majority of cases are caused by genetic defect in the components of the glomerular filtration barrier, specially nephrin and podocin. Other causes of congenital nephrotic syndrome include congenital infections such as syphilis, toxoplasmosis, rubella, cytomegalovirus (CMV), HIV and hepatitis B. We are reporting a case of CNS in a 2 months old male child associated with CMV infection. On routine urine analysis, the patient had heavy (++++) proteinuria without hematuria or pyuria. In 24 hours protein excretion was 12.5 gm/24 hrs, serum total protein 4 gm/dl, serum albumin 2.0 gm/dl, total cholesterol 347.0mg/dl, urinary creatinine 41.0mg%, urinary protein 500mg/dl, protein to creatinine ratio was 12.1:1 and TSH was normal. IgM & IgG antibodies for CMV were raised and maternal IgG for CMV was strongly positive. PCR for CMV in urine was sent and it was positive, which is strongly suggestive of active CMV infection.
Authors and Affiliations
SD Sharma, RK Gupta, Alok Kumar Goyal, Anurag Sarna
Keywords
Related Articles
- EP ID EP616081
- DOI -
- Views 131
- Downloads 0
Superiority of synthetic absorbable sutures over catgut suture in obstetric and gynecology surgeries evidence based review
Some perineal trauma has been reported in more than 85% of women having a vaginal birth. In the UK and US, spontaneous tears requiring suturing are estimated to occur in at least one-third of women. Perineal trauma may r...
Efficacy and safety of fixed dose combination of drotaverine hydrochloride (80 mg) and mefenamic acid (250 mg) versus mefenamic acid (250mg) alone in treatment of primary dysmenorrhea : double-blind, randomised comparative study.
To compare the effect of combination of Mefenamic acid and Drotaverine hydrochloride with Mefenamic acid alone in primary dysmenorrhea. Out of 180 women with diagnosis of primary dysmenorrhea 87 women (Group A) were give...
Insulin motivation : best practices
Under-insulinisation is a key reason that continues to contribute to under-management of diabetes in India. Amongst several factors that lead to failure of initiation and adherence on insulin in Indian patients, psycholo...
Is syndesmotic fixation is necessary in ankle injury, where we stand today?
Syndesmotic injury of ankle is not a very common injury. Treatment of this injury is very challenging and controversies are always there regarding the treatment and fixation methods, the time of weight bearing and remova...
Cardiovascular Manifestations of Dengue Fever Two Case Report and Review article
Dengue is one of the most important viral diseases affecting human beings. The majority of symptomatic infections result in a relatively benign disease course. However, a small proportion of patients develop severe clini...