Connective tissue dysplasia in patients with mitral valve prolapse
Journal Title: Медичні перспективи - Year 2013, Vol 18, Issue 4
Abstract
Recently displasia of connective tissue is much spoken and written about. As a rule, these are scientific articles and reviews in which difficult terms prevail and doctors don't read them up to the end. And the problem, meanwhile, exists, and problem is very interesting. It is known that connective tissue consists of cells, fibers and intercellular substance. It is well known that it may be dense and loose and is widespread throughout the organism – skin, bones, cartilagle, vessels wall, stroma of bodies and even blood – at the basis of every element is connective tissue. The structure of connective tissue is well studied, and all biochemical structures are identified. Successes of molecular genetics allowed to define types, structure and localization of the genes which are responsible for synthesis of various elements. First of all we are interested in fibers of connective tissue – collagen with main function to maintain form, and the elastin, providing ability to reduction and relaxation. Dysplasia of connective tissue – the process genetically determined, i.e. at the basis of everything is mutations of the genes which are responsible for synthesis of fibers. Mutations may be the most various and in the most different genes. As a result of mutations collagen chains are formed incorrectly. Thus, they are shorter (deletion), or longer (insertion), they join not that amino acid (a dot mutation). So-called abnormal trimers of collagen appear, they don't maintain due mechanical loadings. The same is with elastin. The clinical picture will be defined by quantity and quality of mutations. Unfortunately, not only specific appearance and cosmetic defects belong to manifestations of dysplasia of connective tissue, but also heavy pathological changes of internal organs and the musculoskeletal apparatus.
Authors and Affiliations
M. Kuznetsova
Keywords
Related Articles
- EP ID EP120782
- DOI -
- Views 108
- Downloads 0
Prevention of complications after surgical treatment of colpocystocele
78 women with the diagnosis of cystocele were examined. The average age of the examined women was 61.5±9.3 years, the age of women in the control group was 56.7±1.8 years (p>0.05). The results of postoperative treatment...
Dnipro Pharmacology School: a 100 years’ journey (to the centenial of the department of pharmacology and clinical pharmacology of Dnipropetrovsk medical academy). Part I: 1918-1943.
The article presents analysis of the main historical stages of the establishing and development of the scientific school of pharmacology of the SE "Dnipropetrovsk Medical Academy of Health Ministry of Ukraine" for a 100-...
Neurochemical and behavioral processes in gerontogenesis in conditions of experimental hyperglycemia
Many researchers are increasingly interested in the relation between diabetes and diabetic encephalopathy. At the moment, there are various experiments where this issue is considered. But despite prolonged studying, it i...
Гігієнічна оцінка азбестовмісного пилу в повітрі робочої зони теплових електростанцій
На теплоэлектростанциях (ТЭС) в значительных количествах использовался асбест и искусственные минеральные волокна в виде теплоизоляции трубопроводов, герметизирующих прокладок, изоляторов и др. Но до настоящего времени с...
Роль оцінки якості життя та здоров’я з індексом життєдіяльності у пацієнтів з артеріальною гіпертензією в поєднанні з подагрою в практиці сімейного лікаря
Роль оценки качества жизни и здоровья с индексом жизнедеятельности у пациентов с артериальной гипертензией в сочетании с подагрой в практике семейного врача. Лазаренко О.Н., Кузьмина А.П. Количество исследований, которые...