CONSANGUINITY AND RISK OF CONGENITAL DEFECTS- A SYSTEMATIC REVIEW
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 31
Abstract
BACKGROUND Consanguineous unions are associated with an increased susceptibility to various forms of autosomal recessive inherited disease. The role of consanguinity in causation of congenital defects is not clear, as various genetic as well as environmental/ epigenetic factors are involved in their aetiology. In this study, we analysed the effect of consanguinity as a risk factor in occurrence of congenital defects. MATERIALS AND METHODS Systematically reviewed recent and past studies with different designs, methodologies conducted in different regions of world on the same subject and compared their conclusions. The reasons and incidence of consanguineous unions, types of consanguineous unions were assessed. Settings and Design- ESIC Medical, Gulbarga, Department of Anatomy, Systematic Review Article. RESULTS Almost all studies support the view that congenital defects occur commonly in consanguineous couples than non-consanguineous couples, but the study designs varied significantly. CONCLUSION Congenital malformations occur more commonly in consanguineous couples than non-consanguineous couples with first cousins being the commonest type. The available articles have inadequately studied the actual (genetic) role of consanguinity in causation of congenital anomalies with multifactorial aetiology. There is a need of large population-based studies determining influence of consanguinity on occurrence of chromosomal abnormalities, thereby resulting in congenital anomalies.
Authors and Affiliations
Charmode Sundip Hemant, Kadlimatti Huchechesha
Keywords
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- EP ID EP541029
- DOI 10.14260/jemds/2018/798
- Views 58
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