CONSCIOUS SEDATION WITH MIDAZOLAM AND PROPOFOL CONTROLLED BY AUDITORY EVOKED POTENTIALS INDEX DURING SPINAL ANESTHESIA
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 8
Abstract
The purpose was to arrive adequate doses of midazolam and propofol infusion for sedation during spinal anesthesia, and whether AAI could be an indicator of adequate sedation level. Thirty patients aged 30 to 70 years scheduled for spinal anesthesia were premedicated with midazolam 0.06 mg/kg and atropine 0.01 mg/kg intramuscularly 15 minutes before anesthesia. Spinal anesthesia was performed with 10 mg hyperbaric tetracaine. Midazolam 0.02 mg/kg was intravenously administered and propofol infusion was started at 2.5 mg/kg/h and stopped at the end of surgery. To keep auditory evoked potentials index (AAI) between 40 and 60, propofol infusion dose was up and down by 0.5 mg/kg/h every 5 minutes. The Observer’s assessment of alertness/sedation (OAAS) scale was checked every 10 minutes. The discrepancy was judged as AAI outside of 40 to 60 when OAAS scale was 3 or 4. Recovery time was measured as the time from the end of surgery to when OAAS scale became 5. AAI decreased below 40 in 10 minutes after start of sedation. The propofol infusion dose was 1.5 ± 0.75 mg/kg/h. In 180 points measured AAI and OAAS scale simultaneously, 12 points had discrepancy between them. Recovery time was 8.5 ± 2.6 minutes. In conclusion, during spinal anesthesia, after premedication with intramuscular midazolam 0.06 mg/kg, intravenous midazolam 0.02 mg/kg followed by propofol infusion at 1.5 mg/kg/h could provide rapid and adequate sedation. AAI might be useful to keep adequate sedation.
Authors and Affiliations
Tomoki Nishiyama
Keywords
Related Articles
- EP ID EP637225
- DOI -
- Views 147
- Downloads 0
PREVALENCE AND MOLECULAR IDENTIFICATION OF ECHINOCOCCUS GRANULOSUS IN HUMANS AND SLAUGHTERED ANIMALS IN EGYPT
Echinococcus granulosus, hosted by humans and animals, impose serious human health risk and cause significant livestock production loss. It is widely seen endemically in the Middle East countries.The objective of this st...
PHYTOCHEMICAL AND ANTIOXIDANT PROPERTIES OF MANILKARA ZAPOTA (L.) P ROYEN FRUIT EXTRACTS AND ITS FORMULATION FOR COSMECEUTICAL APPLICATION
Manilkara zapota (L.) P fruit extracts were investigated for its bioactive compounds and their potential of natural antioxidant properties for cosmeceutical application. In vitro antioxidant activity of hexane, ethyl ace...
BOHLER'S ANGLE–WHAT IS NORMAL IN THE UNINJURED MAKURDI POPULATION?
Background: Calcaneal fracture is the commonest fracture of the tarsal bones and it is associated with displacement of the posterior facet of the calcaneus with resultant alteration in the normal range of the Bohler’s an...
SUSCEPTIBILITY PATTERN OF EMPIRICAL THERAPY FOR UPPER RESPIRATORY INFECTIONS AT PIGG’S PEAK GOVERNMENT HOSPITAL
Background: The utilization of empirical antimicrobial therapy for the treatment of upper respiratory tract infections (URTIs) has the potential of affecting the susceptibility of URTIs. Methods: A quantitative prospecti...
MICROBIAL BIOFILM IMPACT IN FOOD INDUSTRY AND PREVENTION STRATERGIES
Certain bacteria develop a fortress or biofilm in the environments they colonize which provides shield from antimicrobials and other sanitation process. A biofilm is developed in planktonic (and free/stand-alone) cells i...