Consequences of alcohol use among the HIV positive patients who are on antiretroviral therapy: A prospective study
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 4
Abstract
Background: Alcohol use among HIV-positive individuals is associated with decreased adherence to antiretroviral therapy (ART) and consequently poorer HIV treatment outcomes. Aims and Objective: To study and compare the clinical and biochemical spectrum of people living with HIV/AIDS (PLHA) on Anti-Retroviral therapy with special reference to alcohol. Materials and Methods: Hundred patients who were on Anti-Retroviral therapy were studied in the Department of Medicine G.R. Medical College, Gwalior from February 2016 to September 2017. Patients were divided as cases (n=50; with alcohol abuse) and control (n=50; without alcohol abuse). Hemoglobin, total leukocyte count (TLC), peripheral smear examination, random blood sugar, liver function tests, serum bilirubin, serum protein and serum albumin were estimated. Results: Mean age between both the groups were comparable (35.42±9.38 vs 39.30±9.39; p=0.089). Body weight was significantly increased from 49.27±7.33kg to 53.75±6.85 kg before and after ART therapy respectively among cases and 44.04±6.18 kg to 52.56±8.12 kg before and after ART therapy among control group (p<0.001). CD4 count was significantly increased from 238.96±110.81 before ART to 353.24±127.15 after ART in Cases and 227.22±111.98 before ART to 493.08±117.42 after ART in control (p<0.001). Due to alcohol, among cases less weight gain (4.48 kg in Cases vs. 8.52 kg in control) and less increase in CD4 count (114.28 in cases vs. 265.86 on control) was observed as compared to control group who do not consumed alcohol. Conclusion: HIV positive subject with alcohol use along with ART therapy can have detrimental effects of clinical as well as biochemical parameters which can further deteriorate the disease condition.
Authors and Affiliations
Dr. Dinesh Rajput, Dr. Rakesh Gaharwar, Dr. OP Jatav, Dr. Rahul T Sarode, Dr. Pankaj Kumar Jain, Dr. Narayan Prasad Majhi
Keywords
Related Articles
- EP ID EP585033
- DOI -
- Views 119
- Downloads 0
Pattern of glucose 6 phosphate dehydrogenase deficiency in neonates with hyperbilirubinemia in a tertiary care center
Background: G6PD deficiency leading to neonatal hyperbilirubinemia is not an uncommon disorder in India. However it is highly under diagnosed and poorly reported. Method: In this retrospective study, data of 108 neonates...
Assessment of ovarian tumors with respect to clinicopathological aspects in Indian population
The ovarian tumors manifest a wide spectrum of clinical, morphological, and histological features. Their complex nature, unpredictable behavior, and prognosis and varying therapeutic strategies necessitate an accurate di...
Morphological characteristics influencing the orthodontic extraction strategies: A comprehensive review
Extraction has now been accepted widely in various malocclusions including Angle's class II division1. However, the levels of scientific evidence in orthodontic treatment planning have been weak, and it is unlikely to sy...
Anemia in pregnancy: Epidemiology and it’s determinants
Background: Determinants are nutritional, biological & social which contribute poor pregnancy outcomes both for mother & her infant. With this background the present study was designed to assess severity of anemia in rur...
A study on demographic and clinical profile and outcome of neonates admitted to SNCU of DHH & SLN Medical College, Koraput, Odisha
Background: In India, Neonatal mortality of 28 and early neonatal mortality of 20, contribute to 67% infant mortality. India under INAP (India Newborn Action Plan) targets to achieve single digit neonatal mortality rate...