Considering the Effect of Rosa damascena Mill. Essential Oil on Oxidative Stress and COX-2 Gene Expression in the Liver of Septic Rats
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2019, Vol 16, Issue 4
Abstract
Objectives: Sepsis is a clinical illness with a high rate of mortality all over the world. Oxidative stress is considered the main phenomenon that occurs in sepsis. Rosa damascena Mill. is an ancient herbal plant with high pharmacological activities. Materials and Methods: Cecal ligation and puncture (CLP) as a standard model was used to induce sepsis in rats. Male adult rats were randomly divided into 5 groups. Different doses of R. damascena essential oil (50 and 100 mg/kg.bw) were gavaged orally for 14 days and on day 15 CLP was performed. After 24 h, blood samples and liver tissues were removed in order to measure oxidative stress [myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), glutathione-S-transferase, and ferric reducing ability of plasma (FRAP)] and biochemical parameters [alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), and bilirubin] together with plasma prostaglandin E2 (PGE2) and COX-2 expression. Results: The essential oil was capable of modulating all of the oxidative stress, antioxidant, and anti-inflammatory parameters induced by CLP as characterized by elevations in MPO and MDA levels as well as increases in AST and ALT concentrations concomitant with PGE2 and COX-2 increments. The antioxidant defense system such as GSH and FRAP was also increased in the essential oil treated groups. Conclusion: Our results showed that the essential oil has antioxidative and hepatoprotective activities through reducing the oxidative injury in sepsis caused by CLP.
Authors and Affiliations
Abolfazl DADKHAH, Faezeh FATEMI, Mohammad Reza Mohammadi MALAYERI, Mohammad Hassan Karvin ASHTIYANI, Sakineh Kazemi NOUREINI, Azadeh RASOOLI
Keywords
Related Articles
- EP ID EP684713
- DOI 10.4274/tjps.galenos.2018.58815
- Views 164
- Downloads 0
The Effect of Therapeutic Plasma Exchange on COVID-19 Therapy
No summary
Phytotherapy as a Complementary Medicine for Multiple Sclerosis
Multiple sclerosis (MS) is the most common cause of neurologic disability in adults worldwide. Two main issues have caused MS patients to face several problems. One issue is that the definite cause of MS has not yet been...
Palmitic Acid–Pluronic F127–Palmitic Acid Pentablock Copolymer as a Novel Nanocarrier for Oral Delivery of Glipizide
Objectives: The aim of the present study was to develop nanotechnology-based oral formulations of glipizide to enhance the bioavailability and eliminate the frequent oral administration of the conventional dosage form. G...
The Formulation of Methylene Blue Encapsulated, Tc-99m Labeled Multifunctional Liposomes for Sentinel Lymph Node Imaging and Therapy
Objectives: Methylene blue (MB) is a commonly used dye that can be used for near-infrared (NIR) imaging and photodynamic therapy (PDT) by producing reactive oxygen species after light exposure, inducing apoptosis. The li...
Method Validation of Contact and Immersion TLC-bioautography for Determination of Streptomycin Sulfate in Shrimp
Objectives: Contact and immersion thin layer chromatography (TLC)-bioautography were developed for identification and quantification of streptomycin sulfate in shrimp. Materials and Methods: TLC of streptomycin sulfate...