Considering the Effect of Rosa damascena Mill. Essential Oil on Oxidative Stress and COX-2 Gene Expression in the Liver of Septic Rats
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2019, Vol 16, Issue 4
Abstract
Objectives: Sepsis is a clinical illness with a high rate of mortality all over the world. Oxidative stress is considered the main phenomenon that occurs in sepsis. Rosa damascena Mill. is an ancient herbal plant with high pharmacological activities. Materials and Methods: Cecal ligation and puncture (CLP) as a standard model was used to induce sepsis in rats. Male adult rats were randomly divided into 5 groups. Different doses of R. damascena essential oil (50 and 100 mg/kg.bw) were gavaged orally for 14 days and on day 15 CLP was performed. After 24 h, blood samples and liver tissues were removed in order to measure oxidative stress [myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), glutathione-S-transferase, and ferric reducing ability of plasma (FRAP)] and biochemical parameters [alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), and bilirubin] together with plasma prostaglandin E2 (PGE2) and COX-2 expression. Results: The essential oil was capable of modulating all of the oxidative stress, antioxidant, and anti-inflammatory parameters induced by CLP as characterized by elevations in MPO and MDA levels as well as increases in AST and ALT concentrations concomitant with PGE2 and COX-2 increments. The antioxidant defense system such as GSH and FRAP was also increased in the essential oil treated groups. Conclusion: Our results showed that the essential oil has antioxidative and hepatoprotective activities through reducing the oxidative injury in sepsis caused by CLP.
Authors and Affiliations
Abolfazl DADKHAH, Faezeh FATEMI, Mohammad Reza Mohammadi MALAYERI, Mohammad Hassan Karvin ASHTIYANI, Sakineh Kazemi NOUREINI, Azadeh RASOOLI
Keywords
Related Articles
- EP ID EP684713
- DOI 10.4274/tjps.galenos.2018.58815
- Views 161
- Downloads 0
COVID-19 Pandemic and its Impact on Pharmacy Education
No summary
Comparison of Lipid and Lipoprotein Values of Wrestlers and Soccer Players
Objectives: The aim of this study was to compare the lipid and lipoprotein values of wrestlers and soccer players. Materials and Methods: A total of 35 subjects, 17 male wrestlers who are sporting for 11.5 years and 18...
Synthesis and Swelling Behavior of Sodium Alginate/Poly(vinyl alcohol) Hydrogels
Objectives: Hydrogels are macromolecular networks able to absorb and release water/biological fluids in a reverse-phase manner, in response to specific environmental stimuli. Such stimuli-sensitive behavior makes hydroge...
Comparative In Vitro Assessment of the Methanol Extracts of the Leaf, Stem, and Root Barks of Cnidoscolus aconitifolius on Lung and Breast Cancer Cell Lines
Objectives: Cnidoscolus aconitifolius Mill. I.M.Johnst. is a medicinal plant widely used in ethnomedicine for the treatment of cancer and other diseases. Materials and Methods: The effects of methanol extracts of the le...
Current Overview of Oral Thin Films
The pharmaceutical industry is attempting to discover thin films as a new drug delivery system. Thin films have been described as an alternative approach to conventional dosage forms. They are a versatile platform that p...