Construction of a preoperative lymph node metastasis risk prediction model for colorectal cancer

Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 9

Abstract

Objective To investigate the independent risk factors among preoperative systemic inflammatory indicators associated with lymph node metastasis (LNM) in patients with colorectal cancer (CRC) and to construct and validate a related risk prediction model. Methods Clinical data of 241 patients with CRC who received surgery at Affiliated Xinhua Hospital of Dalian University from January 2012 to December 2017 were retrospective analyzed. Variable selection was performed using univariate analysis combined with Least Absolute Shrinkage and Selection Operator (LASSO) regression and 10-fold cross-validation. After constructing the best logistic regression model, multivariate analysis was conducted to determine the independent risk factors for preoperative LNM in CRC, and a nomogram was developed. The model was internally validated using the Bootstrap method and its predictive performance and clinical utility were evaluated through receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). Results Univariate analysis and LASSO regression with cross-validation identified smoking history, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), fibrinogen-to-albumin ratio (FAR), and fecal occult blood (FOB) as variables with non-zero coefficients. Multivariate analysis using these factors showed that smoking history (OR=2.669, 95%CI: 1.158-6.150, P=0.021), high NLR(OR=1.895, 95%CI: 1.379-2.605, P<0.001), low LMR (OR=0.907, 95%CI: 0.823-0.999, P=0.048), high FAR (OR=1.145, 95%CI: 1.062-1.235, P<0.001), and positive FOB (OR=2.289, 95%CI: 1.132-4.630, P=0.021) were independent risk factors for LNM in CRC (P<0.05). The ROC curve, calibration curve, and DCA curve indicated that the nomogram constructed in this study provided benefits to patients. Conclusion The risk predictive model constructed in this study demonstrated good predictive performance and clinical utility for preoperatively identifying LNM in CRC patients.

Authors and Affiliations

WEN Xuemei , SUN Haoran, DU Shijiang, XIA Junkai, YU Hanchao, ZHANG Wenjun

Keywords

Related Articles

Expression and significance of Toll-like receptor 5 in peripheral blood mononuclear cells of patients with rheumatoid arthritis

Objective To examine the expression levels of Toll-like receptor 5 (TLR5) on peripheral blood monocytes in patients with rheumatoid arthritis (RA), and to explore its clinical significance.  Methods A total of 140 RA pat...

Research progress on the effect of chemotherapy drugs on ovarian function in breast cancer

In women with reproductive potential, ovarian dysfunction caused by chemotherapy for breast cancer has far-reaching effects. Ovarian insufficiency can manifest as amenorrhea, menstrual disorders, hot flashes and night sw...

Exploration on the treatment of gastroesophageal reflux disease by clearing heat and descending the adverse flow of Qi based on “all acid eructation is ascribed to heat”

“All acid eructation is ascribed to heat” is one of the Nineteen items of pathogenesis in the Inner Canon of Yellow Emperor (Huangdi Neijing). This theory underscores the close connection between symptoms such as vomitin...

Effects of laparoscopic surgery combined with hyperthermic intraperitoneal chemotherapy on postoperative coagulation indicators in patients with colorectal cancer

Objective To observe the changes of coagulation function in patients with colorectal cancer (CRC) after laparoscopic surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Methods Sixty patients with CR...

Delivery outcome of primipara with vaginal delivery receiving novel pulse perineal protective delivery technique

<b>Objective</b> To explore the application effect of novel pulse perineal protective delivery technique in primipara undergoing vaginal delivery. <b>Methods</b> A total of 229 primipara who met the indications for vagin...

Download PDF file
  • EP ID EP745458
  • DOI 10.13429/j.cnki.cjcr.2024.09.011
  • Views 10
  • Downloads 0

How To Cite

WEN Xuemei, SUN Haoran, DU Shijiang, XIA Junkai, YU Hanchao, ZHANG Wenjun (2024). Construction of a preoperative lymph node metastasis risk prediction model for colorectal cancer. Chinese Journal of Clinical Research, 37(9), -. https://europub.co.uk/articles/-A-745458