CONSUMPTION AND BACTERIAL RESISTANCE TO AMINOGLYCOSIDES AT SUDANESE UNIVERSITY HOSPITAL
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 8
Abstract
Objectives: The objective of this study was to describe patterns of antimicrobial resistance to gentamicin (Gen) and amikacin (Ak) among Gram-negative aerobic bacteria during 1-year period and to determine the association between antibiotic resistance and the consumption of Gen.Methods: Aminoglycosides consumption at Soba University Hospital wards was measured and susceptibility of Gram-negative bacteria for the same period was evaluated. Consumption data were converted to defined daily doses (DDDs)/100 bed days based on DDD/anatomical therapeutic chemical the WHO system. The association between the frequency of strains resistant to Gen and Ak and their consumption was assessed by linear regression analysis using Spearman’s correlation. The level of statistical significance was set at p<0.05.Results: A total of 973 Gram-negative isolates were identified and tested for antimicrobial susceptibility to Gen and Ak. Resistance to Gen alone was found to be 19.42%; n=189, resistance to Ak alone was found to be 3.08%; n=30, and resistance to Gen plus Ak was found to be 5.24%; n=51. Pseudomonas aeruginosa was the most resistant pathogen to Ak plus Gen (2.26%; n=22). A positive correlation between the increases in the use of Gen and the prevalence of bacterial resistance among hospital wards was found (correlation coefficient r=0.6; p=0.04).Conclusion: Gen and Ak are still highly active antimicrobial agents for the treatment of aerobic Gram-negative bacteria at times of intensified resistance to other antimicrobial agents. Monitoring the use of aminoglycosides is very important too.Â
Authors and Affiliations
Einas A Bakheit, Kamal M Elhag, Abduelmula R Abduelkarem, Nada A Basheer
Keywords
Related Articles
- EP ID EP567379
- DOI 10.22159/ajpcr.2018.v11i8.26381
- Views 142
- Downloads 0
NANOSTRUCTURED LIPID CARRIERS: THE FRONTIERS IN DRUG DELIVERY
By the modification of solid-lipid nanoparticles (SLNs), the nano-structured lipid carriers (NLCs) were obtained by the modification of nanostructured that hold the qualities of the SLN, increases the stability of the dr...
MEASUREMENT OF ANTIOXIDANT POWER OF MOUTHWASHES INDICATED IN STOMATITIS
ABSTRACTObjective: Hospital formulations containing allopurinol and rebamipide are used in the prophylactic and therapeutic management of stomatitis,owing to their antioxidant powers. The objective of this study was to m...
EFFECTS OF ANESTHESIA ON INNATE IMMUNE COMPONENTS IN ORTHOPEDIC SURGERY
Objectives: The present study was carried out to evaluate the possible role of anesthetics and surgery on innate by measuring the levels of tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ) by enzyme-linke...
ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECTS OF CURCUMIN CONTRIBUTE INTO ATTENUATION OF ACUTE GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS
Objectives: Nephrotoxicity is a renal-specific situation in which the excretion of toxic metabolites is reduced due to toxic agents and drugs. Gentamicin is an antibiotic belongs to aminoglycoside group which may induce...
INVESTIGATION OF ANTI-INFLAMMATORY AND ANTINOCICEPTIVE EFFECTS OF AQUEOUS EXTRACTS OF ARTEMISIA AFRA IN WISTAR RATS
Objective: The objective of the study was to evaluate the anti-inflammatory and antinociceptive effects of Artemisia afra.Methods: Animals were randomly divided into five groups of six animals each and administered with...