Consumption Time of Captopril Influenced the Outcomes of Patients with Stage 1 Hypertension
Journal Title: Pharmacology and Clinical Pharmacy Research - Year 2017, Vol 2, Issue 1
Abstract
Differences in drugs consumption time may affect its absorption and metabolism in the body which could lead to differences in its efficacy. For hypertension patients, one of the most frequently used drugs for lowering blood is captopril. However, information regarding the influence of consumption time on captopril efficacy was limited. Therefore, this study was conducted to compare the efficacy of captopril in lowering blood pressure when administered before and after meal. This was an experimental study with two treatment groups, conducted at Dr. Soedarso General Hospital, Pontianak, Indonesia, during April-June 2015. Statistical analysis was performed using Mann-Whitney, Exact-Fisher, and T-test. We found out that the reduction of systolic blood pressure in group who consumed captopril before and after meal was 30 mmHg and 25 mmHg, respectively (p<0.05). The similar reduction in diastolic bloos pressure was observed in both groups (10 mmHg, p>0.05). In conclusion, it is recommended to take captopril on an empty stomach since it showed better efficacy when administered before meal compared to after meal consumption.
Authors and Affiliations
Sulastri Herdaningsih, Ahmad Muhtadi, Keri Lestari
Keywords
Related Articles
- EP ID EP353308
- DOI -
- Views 105
- Downloads 0
Secondary Metabolites and Antioxidant Activity of Methanol Extract of Castanopsis costata Leaves
Castanopsis costata (C.costata) leaves were empirically used by people in North Sumatera, Indonesia, as an antioxidant dietary supplement. However, its pharmacological effect has not been scientifically explored. The pur...
Anti-proliferative Activity of Crotalaria pallida Aiton on MCF-7 Breast Cancer Cells
Crotalaria pallida Aiton (C. pallida Aiton) is empirically used as dietary supplement to treat cancer by the people of North Sulawesi. However, its scientific pharmacology activity has not been explored yet. Therefore, t...
The Effect of Anti-Tuberculosis Drugs on the Effectiveness of Anti-Retroviral Therapy in HIV-AIDS Patients
Tuberculosis is the most common opportunistic infection and a leading cause of death among patients who infected by Humman Immunodeficiency Virus (HIV) in developing countries. The purpose of this study was to determine...
Predictor of Diabetes: Correlation between Leucine Concentration and Insulin Resistance
Leucine catabolism changes among people with central obesity. This condition can lead to metabolic pathway disorder and increased mTORC-1 activation. Downstream signal of mTORC-1 is p70S6K1, which causes phosphorylation...
Acute Toxicity of Ethanol Extract of Polygonum pulchrum Blume using Brine Shrimp Lethality Test Method
The potential toxicity effect presents in the medicinal plants is important to be identified for the safety assurance. Accute toxicity study is an initial step in the drug safety assurance test. Thus, the aim of this stu...