Contribution of Other Parameters to Malignancy Risk Index for Differentiation of Benign or Malignity in Adnexal Masses
Journal Title: Scholars Bulletin - Year 2018, Vol 4, Issue 5
Abstract
Abstract:Ovarian cancer is one of the most important causes of pelvic masses and is the fifth leading cause of cancer related mortality. As in all cancers, method of early diagnosis for ovarian cancer should be easily applicable, economically, has high safety and specificity. Our study included 155 cases that were operated due to adnexial masses at Obstetrics and Gynaecology Clinic of Trakya University. Inclusion criteria for the study were decision of surgery due to an adnexal mass and presence of preoperative evaluation for parameters examined in this study such as age, serum CA125 value, Ultrasound score, menopausal score and thrombocyte count. Risk of Malignancy Indexwas calculated. Localization and amount of vascular flows in adnexial masses were evaluated using Color Doppler USG. Ages of the cases ranged between 17-75 years. Histopathologically 122 benign, 6 borderline, 27 malignant masses were detected. As surgical approach to malignant tumours is similar to borderline tumours, they were assessed within malignant tumour group. Malignancy was suspected in 27 of 155 cases which were evaluated with RMI. Malignancy was suspected in 33 patients evaluated with CDUS and malignancy was suspected in 26 cases evaluated with thrombocyte count. Evaluation of RMI according to histopathological results revealed that there was no difference between the two assessment methods. Specificity of the RMI evaluation was 98.4% and its sensitivity was 75.8%. Thrombocyte count demonstrated malignancy in 16.8% of the cases. Evaluation of CDUS findings revealed that 122 cases diagnosed as malignant in pathology were also diagnosed as malignant in CDUS and the other cases were detected to be benign with Doppler. CA125 values were below 35 U/mL in 86.8% of the cases with benign adnexal masses and above 35 U/mL in 72.7% of the malignant cases. Better preoperative benign-malignant differentiation will enable performance of optimal surgery in experienced centres. RMI which can be used for early detection and differentiation of malignancy has opened the way for objective evaluation of adnexal masses.With use of parameters such as CDUS, thrombocyte count, and age together with RMI benign-malignant differentiation of adnexal masses can be made more effectively. Keywords:Ovarian cancer, pelvic masses, adnexial masses.
Authors and Affiliations
Gülden AYNACI, Ahmet Tolgay Akinci, Vedat Ugurel, Petek Balkanli, Koray Elter
Keywords
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