Controlled Drug Release from Implant Surfaces Against Hospital Infections
Journal Title: Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji - Year 2016, Vol 4, Issue 3
Abstract
Hospital infections are one of the most important factors that affect the success of implant materials. Patients may have strong pain, integration between newly formed tissue and implant material may weaken, revision surgery may be needed, and even implant may be taken back from the patient as a result of infections. In this study, a polymer/metal (chitosan/titanium) system that can be used to prevent infections was tested in controlled antibiotic (gentamicin) release studies. Firstly, antibiotic loaded polymers were immobilized onto titanium substrates and then these samples were exposed to different drying conditions (air drying-freeze drying). Porous structures were formed on the titanium samples after freeze-drying. The effects of porous structure on the amount of released antibiotic from surfaces and osteoblast attachment & proliferation were investigated. As a result, it was shown that porous structures leaded to an increase in released antibiotic amount. Furthermore, cell proliferation test (MTS) showed that cell proliferation was higher on porous chitosan coated surfaces than smooth chitosan coated surfaces, especially at day 5.
Authors and Affiliations
Sakip ÖNDER
Keywords
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