CONTROLLED RELEASE IBUPROFEN NANOPARTICLES: PHYSICO-CHEMICAL CHARACTERIZATION AND DRUG RELEASE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objectives: The effect of lipid phase composition, concentration of lipid and surfactant on the entrapment, morphology, particle size and release profiles of ibuprofen-loaded lipid particles was evaluated.Methods: Formulations containing only a solid lipid (Compritol® 888 ATO) and formulations containing mixture of solid and liquid lipids (Compritol® 888 ATO: Labrafil® M 1944 CS) were prepared at various lipid level (5%, 10% and 15% w/v) and surfactant (1.35% and 3%w/v) concentrations using the hot homogenization method.Results: The particle size distribution was found to be polydisperse with a high concentration of microparticles. The particles were spherical in shape. The preparation method was effective in producing particles with high drug entrapment efficiencies (65% – 100%). Drug release studies showed a controlled release profile that follow diffusion kinetic model for all formulations. High lipid concentrations (10% and 15%) increased drug entrapment capacity and showed low initial burst of the drug during early time of testing dissolution. X-Ray diffraction and NMR studies showed coexistence of both amorphous and crystalline forms of the ibuprofen within the lipid matrix. Addition of Labrafil® led to a more amorphous internal structure by modifying the crystallinity of both ibuprofen and the lipid Compritol®.Conclusions: This investigation solved problems associated with nanoparticlesÂ
Authors and Affiliations
Evone S. Ghaly, Valerie Sastre
Keywords
Related Articles
- EP ID EP579668
- DOI -
- Views 54
- Downloads 0
DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR THE ANALYSIS OF ACETYLCHOLINESTERASE INHIBITOR
Objective: The aim of this research paper was to develop a simple, sensitive, rapid, accurate and economical Ultra Violet spectrophotometric method for the Analysis of Acetylcholinesterase Inhibitor.Methods: The study wa...
VARIABLE RESPONSE OF THREE MORPHOTYPES OF TECOMELLA UNDULATA (SM.) SEEM TOWARDS HUMAN PATHOGENIC BACTERIA
Objective: Medicinal Tree Tecomella undulata [Sm.] Seem belonging to family Bignoniaceae has three distinct morphotypes. Present study was undertaken to assess antimicrobial potential of the three morphotypes of Tecomell...
EFFECT OF METABOLIC SURGERY ON TYPE 2 DIABETES REMISSION: A MATCHED GROUP ANALYSIS
Objectives: In this study it is proposed to analyse the effect of bariatric metabolic surgery on diabetes remission in obese type 2 diabetic patients compared to conventionally treated similar patients.Methods: A retrosp...
BURKHOLDERIA CEPACIA GROWTH IN PRESERVED PHARMACEUTICAL ANTIHISTAMINIC ORAL SUSPENSION
A chemically-preserved oral antihistaminic suspension based on fexofenadine as an active pharmaceutical ingredient and preserved with aminobenzoic acid esters (parabens) was found contaminated with Burkholderia cepacia (...
COMPARATIVE ANALYSIS OF AMYLASE PRODUCTION BY PROTEUS SP FROM DIFFERENT SOIL HABITAT
Objective: The main goal of our study was to isolate the amylase producing bacteria from three different soil samples collected from sewage dumped lake(L), Agricultural field (A), highway (R) and comparative analysis of...