Conventional Synthesis and Characterization of novel Benzothiazole derivatives containing Indole moieties with Anti inflammatory and anti Convulsant Activities.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 5
Abstract
The"(E)-5-chloro-1-((E)-1-((7-chloro-6-fluorobenzo[d]thiazol-2-yl)imino)ethyl)-3-(p-tolylimino) indolin-2-one" was to synthesize, purify, characterize and evaluate the biological activity of newly synthesized structural analogs of Benzothiazole derivatives Indole moieties. All these molecules (5a-5o) were characterized by FTIR, H1NMR and mass spectral analysis along with physical data. The biological potentials of the newly synthesized compounds are evaluated for their anticonvulsant and anti-inflammatory activities. From antiinflammatory evaluations, dose level of 200mg/kg of test compounds reported significantly higher activity when compared to dose level of 20 mg/kg. Moreover, compound 5f, 5h, 5k and 5o (200 mg/kg) resulted in similar antiinflammatory activity when compared with Diclofenac (20 mg/kg). All the compounds were evaluated for their anticonvulsant activity. Three compounds 5e, 5j and 5o showed promising anticonvulsant activities in Maximal Electroshock Seizure test (MES) and phenytoin (dose: 25mg/kg) used as a standard.
Authors and Affiliations
Srinivasa Murthy . M, Aleti Rajareddy
Keywords
Related Articles
- EP ID EP415670
- DOI 10.9790/3008-1305042429.
- Views 96
- Downloads 0
Beneficial Effects of Ethanolic Seed Extract of Cyperus esculentus on Blood Glucose and Sperm Quality in Alloxan-induced Diabetic Rats
Background: An important complication of diabetes mellitus is the disturbance in the male reproductive system. Aim: To determine the effects of ethanolic seed extract of C. esculentus on blood glucose and sperm quality i...
The Nematode Diversity from Sugarcane Fields in Aurangabad Region Maharashtra State, India
The Plant parasitic nematodes of sugarcane are diversely reportable with the connected decline in sugarcane productivity. Soil nematodes were studied in Aurangabad region by choosing four totally different sites. The aim...
Prevalence and management practices of malaria in a rural community of Ebonyi state, southeast Nigeria
A prevalence survey of malaria was carried out in Onicha-Igbeze, a rural community in Onicha Local Government Area of Ebonyi state, southeast Nigeria. Thick blood films of 100 individuals in the community were used to de...
Isolation and Identification of therapeutic compounds from Moringa oleifera and its antimicrobial activity
Moringa oleifera, is commonly known as ‘drumstick tree’ or ‘horseradish tree’. Every part of the plant has high nutritive value. In this study the leaf extracts of Moringa oleifera was prepared using 7 different solvents...
Species Richness And Diversity of Sea Birds And Shore Birds of Red Sea Region In Massawa, Eritrea, North East Africa
Large number of birds are found in Red Sea region since there was no potential predators found in that region and hence the birds were selected it as a feeding and breeding ground for the sea and shore birds. The researc...