Conventional Synthesis and Characterization of novel Benzothiazole derivatives containing Indole moieties with Anti inflammatory and anti Convulsant Activities.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 5
Abstract
The"(E)-5-chloro-1-((E)-1-((7-chloro-6-fluorobenzo[d]thiazol-2-yl)imino)ethyl)-3-(p-tolylimino) indolin-2-one" was to synthesize, purify, characterize and evaluate the biological activity of newly synthesized structural analogs of Benzothiazole derivatives Indole moieties. All these molecules (5a-5o) were characterized by FTIR, H1NMR and mass spectral analysis along with physical data. The biological potentials of the newly synthesized compounds are evaluated for their anticonvulsant and anti-inflammatory activities. From antiinflammatory evaluations, dose level of 200mg/kg of test compounds reported significantly higher activity when compared to dose level of 20 mg/kg. Moreover, compound 5f, 5h, 5k and 5o (200 mg/kg) resulted in similar antiinflammatory activity when compared with Diclofenac (20 mg/kg). All the compounds were evaluated for their anticonvulsant activity. Three compounds 5e, 5j and 5o showed promising anticonvulsant activities in Maximal Electroshock Seizure test (MES) and phenytoin (dose: 25mg/kg) used as a standard.
Authors and Affiliations
Srinivasa Murthy . M, Aleti Rajareddy
Keywords
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- EP ID EP415670
- DOI 10.9790/3008-1305042429.
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