Coordination properties of Palladium(II) complex taken as a model of an antitumour agent with some selected amino acids, peptides and DNA constituents
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 9, Issue 3
Abstract
Pd(DHP)Cl2 complex ( DHP = 1,3-diamino-2-hydroxopropane ), was synthesized and characterized by physico-chemical measurements. The coordination of [Pd(DHP) (H2O)2]2+ with some selected bio-relevant ligands as phenylglycine, phenylalanine, lysine, valine, ethanolamine, glycineamide, glycylphenylalanine, glycylleucine, inosine, guanosine and inosine-5’-monophosphate disodium salt was investigated.Stoichiometry and stability constants of the complexes formed are reported at 25 0C and 0.1M ionic strength. The results show the formation of 1:1 complexes with amino acids. DNA constituents form 1:1 and 1:2 complexes. Peptides form both 1:1 complexes and the coresponding deprotonated amide species. The effect of chloride ion concentration on the formation constant of inosine, taken as a representaive ofDNA constituents, complex with Pd(DHP)2+ was reported.
Authors and Affiliations
Ayser Al-Allousi, Perihan A. Khalf-Alla, Safaa S. Hassan, Mohamed M. Shoukry
Keywords
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- EP ID EP652708
- DOI 10.24297/jac.v9i3.1011
- Views 143
- Downloads 0
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