Coorelation of Hscrp with Urinary Albumin Creatinine Ratio (UACR) in Patients of Diabetes with and Without Nephropathy
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Background: Diabetic nephropathy remains major cause of morbidity & mortality for persons with either Type l or type2 DM.1 India leads the world with largest number of diabetic subjects earning the dubious distinction of being termed the "diabetes capital of the world". Patients with type 2 diabetes comprise the largest and fastest growing single disease group requiring renal replacement therapy (nearly 50-60% of diabetic subjects receiving renal replacement therapy.2 In the past few years, numerous studies have shown that low-grade inflammation is associated with the risk of developing type 2 DM.3 Several recent studies have also shown that patients with type 2 DM and overt nephropathy exhibit high levels of diverse acute phase markers of inflammation, including C-reactive protein (CRP), serum amyloid A, fibrinogen, and IL-6 4,5,6,7,8 This study Was undertaken to investigate the role of subclinical inflammation in the pathogenesis of diabetic nephropathy by evaluating the association between the serum High-sensitivity CRP (HS-CRP) (marker of inflammation) and urinary albumin to urinary creatinine ratio. Methods: A prospective case control study of 100 diabetic patients were taken(50 patients with nephropathy and 50 without nephropathy) all these patients hsCRP was compared with UACR(urine albumin to urine creatine ratio). Result: Mean hsCRP in patients without nephropathy was 1.7046 mg/dL and Mean hsCRP in patients with nephropathy was 8.83054. This difference was found to be statistically significant ( pvalue <0.0001). Mean Hscrp in patients without macro albuminuria was 4.51±6.34.Mean Hscrp in patients with macro albuminuria was 8.71±3.99. This difference was found to be statistically significant ( p value= 0.0089).
Authors and Affiliations
Rahul Chauhan, Ramendra singh, Ritesh Lal
Keywords
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- EP ID EP238850
- DOI 10.9790/0853-1611070104
- Views 88
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