CORRELATION ANALYSIS BETWEEN THE MORPHOMETRIC CHARACTERISTICS OF THE HEAD OF NUCLEUS CAUDATUS AND THE INTENSITY OF PSYCHOTIC MANIFESTATION IN SCHIZOPHRENIA
Journal Title: SANAMED - Year 2018, Vol 13, Issue 2
Abstract
Introduction: One of the significant functional disorders of the central nervous system in patients with schizophrenia is the increased activity of the mesolimbic dopaminergic system. By the nigrostriatal pathway, the caudate nucleus is closely related to other dopaminergic systems of the brain. Since the function of caudate nucleus relies on the action of dopamine in the brain; the role of this anatomical structure in the pathogenesis of schizophrenia is not sufficiently clarified. The aim of this paper was to examine whether the caudate nucleus participates in the modulation of the intensity of psychotic manifestations in schizophrenia. Patients and Methods: The study included a total of thirty-one patients with schizophrenia. Diagnosis of the schizophrenia was based on the DSM-IVcriterion (Diagnostic and Statistical Manual of Mental Disorders, fourth edition), and the intensity of psychotic manifestations was evaluated by using Brief Psychiatric Rating Scale (BPRS). The size of the caudate nucleus was determined on axial non-contrast CT images on the surface of the largest cross-section using AutoCAD 2007 digital morphometry. The statistical data were processed by the SPSS 16.0 program package. The statistical conclusions are presented on the basis of two-tail p <0.05. Results:In this study, we have observed a negative correlation between the area as well as the perimeter of the left caudate nucleus head section and the intensity of the psychotic manifestations (area: regression coefficient B = -0.17, p = 0.050, perimeter: regression coefficient B = -0.010, p = 0.012). On the right hemisphere of the brain we observed only a negative correlation of the intensity of the psychotic manifestations from the perimeter of the head section of caudate nucleus (regression coefficient B = -0.013, p = 0.011). Conclusion: In our research we found that the higher intensity of psychotic manifestations in schizophrenia was accompanied with the smaller area and the perimeter of left caudate head as well as the smaller perimeter of the head of right caudate nucleus. The finding of the dependence of the intensity of psychotic manifestations on the perimeter of the right caudate head and not on its area speaks in favor of the caudate head surface deformations as one of the markers of intensity of psychotic manifestations in patients with schizophrenia.
Authors and Affiliations
Zlatan Stojanovic, Sanja Vukadinovic Stojanovic, Gordana Macanovic
Keywords
Related Articles
- EP ID EP429386
- DOI 10.24125/sanamed.v13i2.226
- Views 118
- Downloads 0
VAGINAL HYSTERECTOMY COMPARED TO ABDOMINAL AND LAPAROSCOPIC HYSTERECTOMIES IN PATIENTS WITHOUT UTERINE PROLAPSE
Introduction: Except for the uterine prolapse indication, vaginal hysterectomy has been less popular than abdominal hysterectomy because the latter is considered safer and easier and surgeons often lack sufficient experi...
DOES BEATING HEART SURGERY TECHNIQUE REDUCE THE MORTALITY AND MORBIDITY AFTER REDO VALVE OPERATIONS?
Aim: The aim of this study was to determine the effect of beating heart technique on mortality and morbidity after redo valve operations. Material and Method: Fifty-two patients who had redo open-heart surgery between M...
PORCELAIN GALLBLADDER: A CASE REPORT
Porcelain gallbladder is an extremely rare variant of chronic cholecystitis. Previous studies have shown that the incidence of gallbladder cancer has reached 60% in patients with porcelain gallbladder, but in more recent...
RELATION TO FUNCTIONAL AND NUTRITIONAL STATUS AMONG HOSPITALIZED ELDERLIES
Introduction: Adding years to life is a great achievement when this is accompanied by a good level of health and well-being and independence. Major indicators for prediction mortality risk in older adults are the nutriti...
THE INFLUENCE OF CHRONIC STRESS ON HEALTH AND COPING MECHANISMS
Stress represents a negative life experience, closely followed by physiological, cognitive, emotional, and behavioral changes that focus on changing the event or adapting to its effects. Any situation or occurrence that...