CORRELATION BETWEEN ANTHROPOMETRIC PARAMETERS WITH LOW DENSITY LIPOPROTEIN RECEPTOR (A370T) GENE POLYMORPHISM IN TYPE II DIABETES PATIENTS OF IRAQI POPULATION
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2019, Vol 5, Issue 4
Abstract
Background: (A370T) is a SNP in the 370th nucleotide in exon 8 of the low density lipoprotein receptor (LDLR) gene where Guanine (2-amino-6-oxy purine) transported to Adenine (6-amino purine) and this substitution is of transition type as each of Guanine and Adenine are purine nitrogen base. The (A370T) SNP causes an amino acid replacement (Alanine to Threonine) in the translated polypeptide. Aim: This study was designed to assess the relationship between the low density lipoprotein receptor (A370T) single nucleotide polymorphism and different anthropometric parameters in type 2 diabetes mellitus patients in Kerbela city. Materials and Methods: A case-control study of 180 patients (90 male and 90 female) with type II diabetes mellitus. Body mass index, serum lipid profiles and fasting blood sugar were measured in sera of each patient (males and females) and the statistical analysis was made by SPSS 22. Results: The results attained in the current study showed that the fasting blood glucose and glycated hemoglobin were significantly higher (p<0.001) in diabetic patients than control subjects. Additionally, data gotten from comparison between males and females within the diabetic patients with dyslipidemia group revealed that females have significantly lower levels of high density lipoprotein cholesterol and higher levels of total cholesterol compared to males (p<0.05) . There was no relationship between the low density lipoprotein receptor (A370T) gene polymorphism and the measured parameters in patients with type II diabetes mellitus. The results of this study agreed with several studies which stated that there was no association between the LDLR gene polymorphism (A370T) with dyslipidemia and any of anthropometric parameters and the (A370T) polymorphism doesn't considered as a risk factor for dyslipidemia development in patients with type 2 diabetes mellitus in Iraqi patients. Conclusion: There was no association between the LDLR gene polymorphism (A370T) with dyslipidemia and any of anthropometric parameters at the study groups and the (A370T) polymorphism doesn't considered as a risk factor for dyslipidemia development in patients with type 2 diabetes mellitus in Iraqi patients.
Authors and Affiliations
Fadhil Jawad Al-Tu’ma
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