Correlation between Atherogenic Factors in Complicated and Uncomplicated Type 2 DM
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 5
Abstract
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. The vascular complications of diabetes mellitus are further divided into micro vascular and macro vascular complications. There is an observed disparity between various vascular complications of diabetes and the atherogenic factors. The objectives were to study the atherogenic factors in type 2 diabetes patients in relation to complications and without complications. The work was carried out in the outpatient department and medical wards of Mamata General Hospital, Khammam. The study was done over a period of one year that included 100 type-2 diabetic patients. Pregnant and lactating women, patients with chronic alcoholism, hepatic, renal and thyroid disorders and Juvenile diabetes were excluded from the study. The investigations included Fasting blood sugar, Post lunch blood sugar, HbA1C, Lipid profile, Lipoprotein (a), Serum homocysteine, Urine albumin, sugar, ECG, Chest X-ray, Patient’s height and weight, Serum creatinine, Fundoscopy. 93% of total patients with poor glycemic control, 18.27% had micro vascular complications and 13.97% had macro vascular complications. 51.61% of complicated diabetes had normal Lpa levels while 48.38% hadelevated levels. 75.36% of uncomplicated diabetes had normal Lp(a) levels and24.63% had elevated Lp(a) levels. Homocysteine was elevated in 58.06% of complicated diabetes and 40.5% ofuncomplicated diabetes while 59.42% of uncomplicated diabetes and 41.93% ofcomplicated diabetes showed normal homocysteine levels. In conclusion, type 2 diabetes mellitus showed a strong correlation between glycemic status and incidence of diabetes complications. Hypercholesterolemia and homocysteine have added to the increased incidence of complications as additional factors in metabolic derangements as a consequence of poor glycemic control. The role of lipoprotein(a) in complications of diabetes need to be evaluated further. There is a strong case for routine addition of vitamin B6, B12, folate in addition to lipid lowering drugs on a routine basis. Keywords: Hypercholesterolemia; Lipo protein (a); Serum Homocysteine.
Authors and Affiliations
V. Krishna Chaitanya K, Dilip M Rampure, C. Rama Krishna, K. Venkateswara Rao
Keywords
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