Correlation between Complications associated with Type 2 Diabetes Mellitus and Platelet Indices
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2018, Vol 6, Issue 1
Abstract
Background: Diabetes mellitus is a disease characterized by either deficiency of insulin or its peripheral resistance resulting in hyperglycaemic and non enzymatic glycation of protein.Several studies have revealed that platelet with increase number and size possibly affecting the platelet distribution width contributing in the pathogenesis of vascular complication. The present study was conducted with the aim to establish the correlation between complications associated with type 2 diabetes mellitus and platelet indices. Materials and methods: The present study was conducted on 150 patients in the Department of Medicine in collaboration with Department of Biochemistry and Department of Pathology at GMC Patiala. The study was divided into two groups Group I: without microvascular complications and Group II with microvascular complications, and Group-A (HbA1c ≤ 7%),Group-B(HbA1c>7%). At least two microaneurysms and/or retinal haemorrhage and/or signs of retinal damage were considered as Diabetic Retinopathy. Student t test was applied as a test of significance and p value of less than 0.05 was considered as significant. Results: The mean Platelet crit amongst Group I subjects was 0.24±0.67 and amongst Group II subjects was 0.30±0.22. The p value was 0.02. The mean HbA1c in Group A was 6.56% and that in Group B was 9.20% with a mean RBS/FBS of 163.30 mg/dl in Group A and 243.50 mg/dl in Group B. It was also found in our study that mean age of patients of Group A was less i.e. 48.82 years as compared to Group B in which it was 53.58 years. Conclusion: All platelet indices (MPV, PDW, Platelet Crit, P-LCR, Platelet Count were significantly increased in patients with nephropathy than in patients without of nephropathy.
Authors and Affiliations
Sanjay Goyal, Vijay Kumar, Satish Sachdeva, Anjali Nagpal
Keywords
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