Correlation between Cytochrome P450, 5-alpha Reductase, and Androgen Receptor Levels in Patients with Type 2 Diabetes Mellitus
Journal Title: Iranian journal of diabetes and obesity (IJDO) - Year 2022, Vol 14, Issue 1
Abstract
Objective: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases. The CYP450 plays an important role in the biosynthesis of steroid hormones and the hormonal activity is mediated by the androgen receptor (AR) and the enzyme 5-alpha reductase (5αR). Therefore, this study aimed to investigate the relationship between these factors in T2DM. Materials and Methods: This case-control study was performed with 60 volunteers, including 30 diabetics and 30 healthy individuals. Demographic information of individuals was recorded and levels of CYP450, 5αR, and AR were measured in serum by ELISA. Data were analyzed by SPSS v.26 version and the significance level was less than 5%. Results: There were no significant difference between diabetics and healthy individuals in gender (P= 1), body mass index (P= 0.199), diastolic pressure(P= 0.466), uric acid(P= 0.202), creatinine(P= 0.627), low-density lipoprotein (P= 0.572), high-density lipoprotein(P=0.692); But there was a significant difference in systolic pressure(P= 0.034), triglyceride(P= 0.0001), and insulin(P= 0.003), between diabetics and healthy individuals. The distribution of CYP450, 5αR and AR in two groups shows that the level of all three factors is higher in diabetic people (P= 0.0001). Also, glycosylated hemoglobin and insulin have a direct relationship with CYP450 (P= 0.0001, R=0.494; P= 0.043, R=0.263), 5αR (P= 0.0001, R=0.808; P= 0.016, R=0.309) and with AR (P= 0.0001, R=0.836; P= 0.011, R=0.326). Conclusion: These results showed that there was a relationship between the levels of CYP450, 5αR, and ARs with T2DM which may explain hormonal changes in diabetic people and the different responses to treatment.
Authors and Affiliations
Mustafa Ali Hasan Aljanabi,Masoud Homayouni Tabrizi1,Vahid Pouresmaeil,
Keywords
Related Articles
- EP ID EP700563
- DOI 10.18502/ijdo.v14i1.8738
- Views 89
- Downloads 0
Family Medical History (Knowledge, Attitude) and Management Practices of Diabetes Patients Attending Medical Out Patient Department in Federal Capital Territory Abuja
Objective: The study assessed the knowledge, attitude and management practices of diabetes patients attending medical out- patient department in Federal Capital Territory Abuja. Materials and Methods: A total of 120 ran...
Exploring the Relationship of Emotional Intelligence and Obesity among University Students
Objective: Obesity is related to emotional pressures and psychological disorders. Psychiatric disorders, acute psychological stress, psychological problems, and emotional factors induce obesity. This study aimed to inves...
Evaluation of Restless Leg Syndrome in Patients with Type 2 Diabetes Mellitus
Objective: To evaluate restless leg syndrome (RLS) in type 2 Diabetes Mellitus (T2DM) in Lahore. Materials and Methods: A cross-sectional study design was recruited for this study. Non-probability purposive sampling tech...
Simultaneous Effects of Metformin and Sitagliptin on the Contents of Insulin Resistance Proteins Glucose Transporter 4 and Protein Kinase B in Diabetic Patients\' Adipose Tissue
Objective: Obesity is a factor in the development of insulin resistance and type 2 diabetes. Obesity contributes a wide variety of metabolic changes such as insulin resistance. The insulin signal mechanism to intra-cells...
Effect of Concurrent Resistance-Aerobic Training on Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Pediatric Type 1 Diabetes: A Randomized Trial
Objective: The role of post-exercise on the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is not evident in pediatrics with type 1 diabetes (T1D) yet. This paper reports the results of a research...