Correlation between Cytochrome P450, 5-alpha Reductase, and Androgen Receptor Levels in Patients with Type 2 Diabetes Mellitus
Journal Title: Iranian journal of diabetes and obesity (IJDO) - Year 2022, Vol 14, Issue 1
Abstract
Objective: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases. The CYP450 plays an important role in the biosynthesis of steroid hormones and the hormonal activity is mediated by the androgen receptor (AR) and the enzyme 5-alpha reductase (5αR). Therefore, this study aimed to investigate the relationship between these factors in T2DM. Materials and Methods: This case-control study was performed with 60 volunteers, including 30 diabetics and 30 healthy individuals. Demographic information of individuals was recorded and levels of CYP450, 5αR, and AR were measured in serum by ELISA. Data were analyzed by SPSS v.26 version and the significance level was less than 5%. Results: There were no significant difference between diabetics and healthy individuals in gender (P= 1), body mass index (P= 0.199), diastolic pressure(P= 0.466), uric acid(P= 0.202), creatinine(P= 0.627), low-density lipoprotein (P= 0.572), high-density lipoprotein(P=0.692); But there was a significant difference in systolic pressure(P= 0.034), triglyceride(P= 0.0001), and insulin(P= 0.003), between diabetics and healthy individuals. The distribution of CYP450, 5αR and AR in two groups shows that the level of all three factors is higher in diabetic people (P= 0.0001). Also, glycosylated hemoglobin and insulin have a direct relationship with CYP450 (P= 0.0001, R=0.494; P= 0.043, R=0.263), 5αR (P= 0.0001, R=0.808; P= 0.016, R=0.309) and with AR (P= 0.0001, R=0.836; P= 0.011, R=0.326). Conclusion: These results showed that there was a relationship between the levels of CYP450, 5αR, and ARs with T2DM which may explain hormonal changes in diabetic people and the different responses to treatment.
Authors and Affiliations
Mustafa Ali Hasan Aljanabi,Masoud Homayouni Tabrizi1,Vahid Pouresmaeil,
Keywords
Related Articles
- EP ID EP700563
- DOI 10.18502/ijdo.v14i1.8738
- Views 75
- Downloads 0
KK College of Pharmacy, Gerugambakam, Chennai, India.
Objective: This study aimed to conduct a systematic review about diabetes mellitus and COVID-19 severity, management, and mortality. Materials and Methods: Thirteen studies were included in this review, comprising a tota...
Comparison of the Effects of Total Body Resistance Exercise and Traditional Resistance Training on the Immune System Biomarker in Inactive Obese Women
Objective: This study aimed to compare the effect of eight weeks of traditional resistance training and total body resistance exercise (TRX) on the immune system of obese sedentary women. Materials and Methods: In this...
HbA1c in Polycystic Ovary Syndrome as the Cardiac Risk Assessment
Objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with hyperandrogenism marked with hirsutism and ovarian dysfunction. These conditions may lead to the risk of insulin resistance (IR), type...
Effect of Interval Resistance Training with Different Intensities on Some Selected Adipokines in Obese Men
Objective: Adipose tissue-derived adipokines affect cardiometabolic health. This study aimed to evaluate the effect of interval resistance training with different intensities on leptin, adiponectin, and acrosin levels in...
The Transformative Role of Artificial Intelligence in Diabetes Treatment
Dear Editor, I am writing to draw attention to the remarkable advances of artificial intelligence (AI) in the field of diabetes treatment. Artificial intelligence (AI) and machine learning (ML) are revo...