Correlation between Dyslipidemia and Markers of Inflammation in Pre-Diabetic and Diabetic Population.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 6
Abstract
Diabetic mellitus is associated with cardiovascular risks that are further aggregated by the presence of dyslipidemia and alteration in inflammatory pathophysiology. Early management dyslipidemia and improvement of dearranged inflammatory state aid in prevention of atherogenic cardiovascular complications. Therefore this study was commenced with an aim to determine the possible link between lipid parameters and inflammatory mediators and their role in the development of cardiovascular disease in patients with pre-diabetes and diabetes. With the involvement of 371 participants (100 control), 145 pre-diabetes and 126 Diabetes), the study was proceed at Santosh medical college. Fasting Glucose, HbA1C lipid profile and inflammatory mediayors we assessed in each participants. We found significantly increased levels from glucose, HbA1C, cholesterol, TG and LDL as the participants progressed from normoglycemia pre-diabetes- diabetes while level of HDL was significantly reduced. Similarly in case of inflammatory mediators adiponectin showed decreasing trend while CRP, FGn, IL-6 and UA showed increasing trend W-R-T blood glucose level. We also observed positive association of lipid parameters (CHO, TG, LDL) with CRP, FNn, IL-6 and UA and negative association with LDL. The reverse result was obtained in case of adiponectin. Regarding the level of statistical significant, the result were more significant in case of overt diabetes compared to latent pre-diabetes. Both lipid profile and inflammatory markers are altered in patients with pre-diabetes and diabetic patients thus in creaning the risk CVD, So timely improvement in their level can arrest the deleterious health outcomes. Role of inflammatory markers in predicting risk of prediabetes and diabetes.
Authors and Affiliations
Dr Pradeep Kumar
Keywords
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