Correlation between glycosylated hemoglobin level and lipid profile in patients with Diabetes mellitus
Journal Title: International Journal of Advanced Biochemistry Research - Year 2017, Vol 1, Issue 1
Abstract
The present study was conducted in the Department of Biochemistry, M.N.R. Medical College, Sangareddy District, Telangana, State, India. A total of n=75 subjects were selected, comprising n=50 subjects (n=25 male and n=25 female) with known Diabetes mellitus and n=25 non-diabetic healthy controls. The study was aimed to investigate the pattern of dyslipidemia among the subjects and understand its association with glycosylated hemoglobin (HbA1c) level in diabetic and healthy controls. Biochemical parameters were estimated by following standard methods. The mean and SD values of fasting blood glucose (164.56 ± 10.41) and post prandial blood glucose (228.60 ± 12.66) were significantly (p<0.05) increased in diabetic cases compared to non-diabetic controls (84.44 ± 5.04 and 123.64 ± 6.20 respectively). The mean and SD of HbA1c (8.88 ± 0.49) in diabetic cases were significantly higher compared to controls (5.08 ± 0.45). Poor glycemic control indicated by HbA1c level >8 was seen in n=34 (68%) of diabetic patients. Poor glycemic control was associated with dyslipidemia in n=24 (48%) diabetic patients. Whereas, 6 cases (12%) showed worse glycemic control with HbA1c level > 9%, and 8 cases showed good glycemic control with HbA1C level ≤ 6%. The mean±SD of serum total cholesterol (216.48 ± 10.87), triglycerides (214.84 ± 8.98), LDL-cholesterol (149.52 ± 5.06) were significantly (p<0.05) high in diabetic cases over controls (167.68 ± 6.83, 154.84 ± 5.38 and 92.12 ± 5.36 respectively). HDL-cholesterol (31.83 ± 4.42) was significantly reduced in diabetic patients compared to controls (46.94 ± 6.84). The lipid profile values in female diabetic and non-diabetic subjects were slightly increased compared to male subjects. However, the values were not statistically significant. This study showed a significant correlation between levels of glycosylated hemoglobin (HbA1c) and lipid profile. This may help in predicting the lipid profile levels from the degree of glycemic control and therefore, identifying the patients with increased risk of diabetic complications.
Authors and Affiliations
Dr. Madhusudan Rao Sirivole MD, Sadhvimani Eturi
Keywords
Related Articles
- EP ID EP529256
- DOI -
- Views 65
- Downloads 0
Human chorionic gonadotropin levels as a biochemical markers in pregnancy induced hypertension
Pregnancy Induced Hypertension and its sequel are severe complications of pregnancy. The prognostic significance of high levels of serum free β-hCG in early pregnancy for subsequent obstetric and perinatal risks is still...
Pattern of inbreeding in thalassemia affected families resident in Tuman Leghari district Dera ghazi khan
The inbred marriages are highly acceptable in many populations of human beings but their prevalence and configuration vary depending on ethnicity, religious conviction, learning and socioeconomic circumstances of relevan...
Beneficial effects of green tea Epigallocatechin gallate on liver functions and hematological parameters in normal and induced rats by aluminum oxide nanoparticles
The aim of this study was to evaluate the possible beneficial effects of EGCG on Liver Functions and Hematological Parameters in rats induced by Aluminum oxide nanoparticles. Eight groups of rats were used; Group1, contr...
Anticancer effect of the ethanol extract of Annona muricata L. leaves and fruit in cancer induced mice
Objective: The present study was carried out to evaluate the anticancer property of ethanol extract of Annona muricata L. Leaves and fruit against Ehrlich ascites carcinoma in Swiss albino mice. Materials and Methods: Th...
Correlation between glycosylated hemoglobin level and lipid profile in patients with Diabetes mellitus
The present study was conducted in the Department of Biochemistry, M.N.R. Medical College, Sangareddy District, Telangana, State, India. A total of n=75 subjects were selected, comprising n=50 subjects (n=25 male and n=2...