Correlation between intestinal flora characteristics and hepatic and renal impairments in HIV-infected heterosexual men
Journal Title: Shanghai Journal of Preventive Medicine - Year 2023, Vol 35, Issue 12
Abstract
ObjectiveTo explore the relationship between the intestinal flora and the impairment of liver and kidney in HIV-infected men who have heterosexual sex with healthy women.MethodsFecal samples from 41 HIV-infected heterosexual men who have sex with women ï¼PMSWï¼ and 43 age- and BMI-matched healthy heterosexual men who have sex with women ï¼NMSWï¼ were collected and subjected to 16S rDNA sequencing. The blood levels of ASTï¼ ALTï¼ TBILï¼ UREAï¼ Crï¼ UAï¼ Î²2-MG and other liver and kidney function indicators were measured. Bioinformatics methods were used to analyze the characteristics of the intestinal flora of the patients in these two groupsï¼ to compare the differential bacteria strainsï¼ and to analyze their correlation with liver and kidney function indicators.ResultsIn comparison with NMSWï¼ the alpha diversity of intestinal flora was decreased in PMSWï¼ and the beta diversity analysis showed significant differences in flora characteristics between the two groups ï¼P<0.05ï¼. The abundance of Clostridiumï¼ Phylum thick-walledï¼ Trichosporonï¼ and Clostridium tumefaciens decreased but Fusobacteriota increased ï¼LDA score >4ï¼. The comparison of liver and kidney function indexes revealed that ASTï¼ Î²2-MG levels were higher in PMSW than in NMSWï¼ while TBIL was lower in PMSW than in NMSW. The number of patients with abnormal β2-MG was much higher in PMSW than in NMSWï¼ and the difference was statistically significant ï¼P<0.001ï¼. It was also found that AST was negatively correlated with Clostridium ï¼P<0.05ï¼ï¼ TBIL was negatively correlated with Clostridium and positively correlated with Phylum thick-walled and Trichosporon ï¼P<0.05ï¼. β2-MG was negatively correlated with Phylum thick-walledï¼ Clostridiumï¼ Trichosporon and Rumenococcus ï¼P<0.05ï¼ and positively correlated with Clostridium ï¼P<0.05ï¼.ConclusionIn PMSW groupï¼ the alpha diversity of the flora is decreased. AST and β2-MG levels are increasedï¼ and TBIL level is decreased. These changes were significantly correlated with different strains of bacteria in the intestinal flora.
Authors and Affiliations
MA Mingjun,HUANG Jialu,ZHU Lidan,CHEN Panpan,ZHANG Yong,ZHANG Haoran,XU Qiuli,LIU Qianqian,XIAO Shaotan,XIN Xin,
Keywords
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