Correlation between Late-onset Neutropenia, Sepsis and Associated Factors in Preterm Infants: A single center study
Journal Title: Iranian Journal of Blood and Cancer - Year 2018, Vol 10, Issue 1
Abstract
Background: Late onset neutropenia (neutropenia after 3 weeks of life) may be a physiological condition without need to prescribe antibiotics, G-CSF, or IVIG. We aimed to determine the association between sepsis and late onset neutropenia in very low birth weight (<1500 gm) infants. Methods: This study was a cross-sectional prospective study in VLBW infants that were admitted in Mahdieh Hospital in Tehran/Iran. Complete blood count (CBC) was drawn at first day of admission and then weekly intervals until discharge from the hospital. In cases with neutropenia, CRP and blood cultures were assessed and correlation between clinical sepsis or positive blood culture and CRP with neutropenia was evaluated. Results: 219 VLBW infants during a period of 11 weeks were studied with serial weekly CBCs. 128 (58%) neonates had normal neutrophil counts, 91 (41.6%) had neutropenia, of which 28 (30.7%) had late onset neutropenia. Mean level of WBC was 5033.07±2037.57 cells/mm3 and mean level of ANC was 1757.75±944.32 cells/mm3. Positive blood culture at first week of life had significant correlation with neutropenia (P=0.001), but there was no significant correlation between late onset neutropenia and positive CRP (P=0.861), clinical symptoms of sepsis (P=0.5) and bacteremia (P=0.861). There was significant correlation between anemia (P<0.001) and IVH (P<0.007) without any significant correlation with asphyxia (P<0.223) and IUGR (P<0.123) with late onset neutropenia. Conclusion: VLBW infants admitted to the NICU with late onset neutropenia without symptoms of sepsis do not need any intervention and close observation with follow-up would be the most appropriate approach.
Authors and Affiliations
Minoo Fallahi, Abolfazl Afjeh, Naeemeh Taslimi, Mohammad Kazemian, Masoumeh Pandi, Salehe Tajalli
Keywords
Related Articles
- EP ID EP358586
- DOI -
- Views 82
- Downloads 0
Treatment of Newly Diagnosed and Relapsed Hodgkin Lymphoma in Children
Hodgkin lymphoma (HL) accounts for about 10% of all childhood cancers. Five-year survival rates with modern therapies are now approaching >90-95% as a consequence of its significant sensitivity to both chemotherapy and r...
A New Two Step Induction Protocol for Neural Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells
Background: In this study, we examined a new two step induction protocol for improving the differentiation of human umbilical cord blood-derived mesenchymal stem cells into neural progenitor cells. Materials and Methods:...
Determining Serum Zinc Level in Children with Cancer before and 3 Months after Chemotherapy in Kerman Province, Iran
Introduction: Cancer and chemotherapy could decrease serum Zinc level. In this study, serum Zinc level was investigated at the beginning of cancer diagnosis and 3 months after chemotherapy in children with all types of c...
University Students Awareness and Attitude towards Blood Donation in Kerman City
Background: Blood transfusion is one of the most crucial needs of the society in multiple diseases and injuries. The only source of blood is donation. Students consist a large and healthy group who are able of providing...
In vitro Evaluation of the antibacterial activity of Platelet-rich Plasma against Selected Oral and Periodontal Pathogens
Background: Despite the availability of a wide range of antibiotics, bacterial infections are among important challenges for the healthcare system. Therefore, the introduction of new antimicrobial preparations such as pl...