Correlation between level of sodium/iodide symporter expression in tissue sections and some clinical parameters in patients with nodular goiter
Journal Title: Archives of Medical Science - Year 2006, Vol 2, Issue 4
Abstract
Introduction: The aim of the study was to correlate the level of NIS expression in hot, warm and cold nodules with some clinical parameters such as TSH, FT3, FT4, TG, TPO-Ab, TG-Ab, TSH-R-Ab in serum samples, iodine in morning urine samples and thyroid volume. Based on these correlations we tried to find clinical factors that interact with NIS expression in benign nodules and at the same time indicators of NIS expression. Material and methods: The study population consisted of 97 people who underwent surgery for toxic nodular goiter (26 people) or non-toxic nodular goiter (71 people). NIS expression was detected by immunohistochemistry on tissue sections of benign nodules and extranodular parenchyma. The level of NIS expression was estimated objectively using a computer program. Results: The study results demonstrated a significant inverse correlation between the level of NIS expression and FT3 in serum samples in the whole study population and in the group of patients with warm nodules who were not treated with thyreostatics. Furthermore, we revealed a significant inverse correlation between the level of NIS expression and serum concentration of TSH-R antibodies in patients with hot nodules. Additionally, a significant inverse correlation between the level of NIS expression and thyroid volume was investigated in the group of patients with nontoxic nodular goiter. Conclusions: Our data indicate the autoregulatory effect of FT3 on NIS expression. Furthermore, it seems that enlargement of thyroid volume in nontoxic nodular goiter coexists with decreased level of NIS expression.
Authors and Affiliations
Anhelli Syrenicz, Małgorzata Wolny, Andrzej Kram, Krzysztof Sworczak, Barbara Garanty-Bogacka, Mieczysław Walczak
Keywords
Related Articles
- EP ID EP139136
- DOI -
- Views 165
- Downloads 0
Incidence of mortality in 1,040 patients with coronary heart disease or hypertensive heart disease with normal and abnormal left ventricular ejection fraction and with normal and abnormal QRS duration
Anaesthetic management for liver resection in a patient with myelodysplastic syndrome
Postconditioning: a brief review
Preconditioning represents the most effective form of cardioprotection that can be induced to attenuate the injury accompanying a longer lasting ischemia (=index ischemia) of sufficient duration and severity to cause myo...
Current advances in statin treatment: from molecular mechanisms to clinical practice
Statins: much more than cholesterol reduction