Correlation between low density lipoprotein subtype and acute cerebral infarction in patients with type 2 diabetes mellitus
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 12
Abstract
Objective To investigate the relationship between low density lipoprotein (LDL) subtypes and acute cerebral infarction (ACI) in type 2 diabetes mellitus (T2DM). Methods A retrospective analysis was conducted on 292 T2DM patients admitted to Nanjing Jiangbei Hospital from October 2020 to December 2022. According to the brain magnetic resonance examination results, the patients were divided into T2DM without ACI group (group A,n=157) and T2DM with ACI group (group B,n=135). High resolution polyacrylamide gel electrophoresis and automatic biochemical analyzer (Beckman AU5800) were used to measure the levels of each LDL subtype and total cholesterol (TC) of the two groups of subjects, and compare the differences of blood lipids among the groups under traditional risk factors. Logistic regression analysis was used to identify risk factors for T2DM combined with ACI. Results The LDL2, LDL3, LDL4, LDL5, TC, LDL in group B were significantly higher than those in group A (P＜0.05). Multivariate logistic regression analysis showed that elder age, hypertension, high levels of LDL2 and LDL4 were independent risk factors for T2DM complicated with ACI; The ROC curve showed an AUC of 0.843. Conclusion Compared with simple T2DM, the level of LDL2, LDL3, LDL4, and LDL5 are significantly increased in T2DM combined with ACI, and high levels of LDL2 and LDL4 may be independent risk factors for T2DM patients combined with ACI.
Authors and Affiliations
ZHANG Renhe, YUAN Tailei, WANG Yurong, WANG Yan
Keywords
Related Articles
- EP ID EP753811
- DOI 10.13429/j.cnki.cjcr.2024.12.015
- Views 29
- Downloads 0
Correlation between microstream PETCO2 and PaCO2 in patients with general anesthesia after tracheal catheter removal
Objective To evaluate the correlation between microstream partial pressure of end-tidal carbon dioxide (PETCO2) and arterial partial pressure of carbon dioxide (PaCO2) in patients with general anesthesia after tracheal...
Clinical efficacy and safety of PD-1 inhibitor combined with apatinib in the third line treatment of HER2-negative advanced gastric cancer
"<b>Objective</b> To explore the efficacy and safety of programmed cell death receptor 1 (PD-1) inhibitor combined with apatinib in the treatment of human epidermal growth factor receptor2 (HER2)-negative advanced gastri...
Meta-analysis of incidence and risk factors of immune checkpoint inhibitor-associated pneumonia in patients with lung cancer
<b>Objective</b> To systematically evaluate the incidence and risk factors of immune checkpoint inhibitor-associated pneumonia (CIP) in patients with lung cancer. <b>Methods</b> The literature evaluating the incidenc...
Experimental study on the protection of spinal motoneurons by using glatiramer acetate based on a rat model of nerve stumps
Objective To determine the activation of glial cells after brachial plexus injury (BPI), and to explore whether glatiramer acetate (GA) can improve the survival rate of spinal motoneurons of nerve stumps by inhibiting th...
Progress in the diagnosis and treatment of severe fever with thrombocytopenia syndrome
Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging tick-borne infectious disease caused by the Dabie bandavirus (DBV), with an increasing incidence rate each year and a case fatality rate of up to 30%...