Correlation between Low Grade Inflammation with Endothelial Progenitor Cells Surface (EPCs) Marker in Hypertension
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2012, Vol 1, Issue 1
Abstract
Patients with hypertension have been shown to express reduced number and functional capacity of endothelial progenitor cells (EPCs). Recent study reveals that EPCs contain an important capability to maintain endothelial integrity and vascular homeostasis. Therefore, enhancement of EPCs could be benefit for individuals with cardiovascular diseases. We investigated the correlation between low grade inflammation marker (hsCRP) with EPC surface marker (CD34 total) in hypertension. This was an observational study with cross sectional design conducted in 51 nonhypertenive and 60 hypertensive subjects. hsCRP (as marker of inflammation) was measured by immunochemiluminometric method. CD34 total (as marker of EPC) was measured by flow cytometry method. hsCRP concentration was higher in hypertensive subjects compare to nonhypertensive subjects (mean±SD, 2.709±2.50 vs 2.476±2.438 mg/L; P>0.05). CD34 total level was lower in hypertensive subjects compare to nonhypertensive subjects (mean±SD, 1.957±0.858 vs 3.244±3.463/μL; P<0.05). hsCRP had positive correlation with CD34 total in hypertensive subjects (P<0.05). The increasing concentration of hsCRP will stimulate the CD34 total level in hypertensive subjects as demonstrated by the positive correlation between hsCRP with CD34 total.
Authors and Affiliations
Johnson Widjaja, Syakib Bakri, Marsetio Donosepoetro
Keywords
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