Correlation between Muscle Tone and Motor Delay and Biochemical Levels of Carbohydrates in Urine
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 10, Issue 10
Abstract
Aims: To establish a possible correlation between children’s clinical status and carbohydrates in their urine samples as they could be a useful additional tool for objective assessment of muscle tone and motor development. Place and Duration of Study: The Department of Child, Adolescent and Developmental Neurology, University Children’s Hospital in Ljubljana between December 1, 2011 and August 31, 2013. Methodology: The retrospective part of the study comprised children aged 0-5 years (average age, 29.3 months) with motor developmental delay and/or abnormal muscle tone. A group of healthy individuals comprised the prospective part. Besides clinical assessment, electrochemical detection of ten sugars in the urine samples was performed using ion chromatography combined with electrochemical detection and tandem mass spectrometry. Results: 72.0% of 82 hospitalised children had a disorder of muscle tone and/or DQ < 70, 28.0% had a pathological urine sample and an abnormal clinical examination, while 44.0% of children had a clinical abnormality and a normal urine sample. In the control group, 22.7% had pathological urine samples. There was a statistically significant difference between patients and control subjects in the value of fucose (p = 0.020), sucrose (p = 0.051) and ribose (p = 0.000). Conclusion: A significant correlation was found between abnormalities in clinical status and pathological urine samples (p = 0.002). Absolute and relative values of specific carbohydrates and the number of elevated sugars showed a strong correlation with disease severity.
Authors and Affiliations
Ajda Anzic, David Neubauer, Maja Jekovec-Vrhovsek
Ambulatory Phonation Monitor as an Indicator of Voice Use Profile in a Group of Speech Language Pathologists
Aim: Speech-language pathologists (SLPs) can be recognized as professional voice users, as their job depends mainly on healthy and intact voices. The purpose of this study was to explore the vocal load characteristics in...
The Implementation of an Effective Aerobic Walking Program Based on Ottawa Panel Guidelines for Older Individuals with Mild to Moderate Osteoarthritis: A Participant Exercise Preference Pilot Randomized Clinical Trial Protocol Design
Aims: Osteoarthritis is the most common disabling disorder affecting particularly knees. A recent systematic review demonstrated the efficacy of walking programs for improving pain, functional status, endurance, and qual...
Plasma Fibrinogen in Chronic Obstructive Pulmonary Disease – A Cross Sectional Study Conducted in a Tertiary Care Hospital in Puducherry, India
Background: Chronic Obstructive Pulmonary Disease (COPD) is a systemic disorder rather than a respiratory disease. A significant complication that COPD can lead to a hypercoagulable state, which can lead to life-threaten...
Autoimmune Liver Diseases in Native Black Africans: Extremely Rare or Inadequately Investigated Diseases?
Background: Autoimmune liver diseases (autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis) are conventionally considered to be very rare among native black Africans where chronic hepatitis...
Knowledge of Primary Health Care Providers in Nairobi East District, Kenya, Regarding HIV-related Oral Facial and Other Common Oral Diseases and Conditions
Background: In the Kenya primary health care (PHC) setting where most patients, including nearly 1.4 million HIV-infected people, seek medical care, PHC providers are expected to identify and manage HIV-related oral dise...