CORRELATION BETWEEN SERUM GAMMA GLUTAMYL TRANSFERASE AND GESTATIONAL DIABETES MELLITUS IN PREGNANCY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 9
Abstract
BACKGROUND The incidence of Gestational Diabetes Mellitus is increasing in recent years. Gestational Diabetes Mellitus has significant maternal and perinatal mortality. Hence it is important to identify a screening test in the early pregnancy period so that preventive measures can be used to avoid maternal and fetal adverse effects. The aim of this study is to evaluate the relationship between Serum Gamma Glutamyl Transferase (Serum GGT) and Gestational Diabetes Mellitus in the first trimester. Previously many studies have been conducted showing positive correlation between them in the mid trimester of pregnancy. Here sufficient time is not available to take preventive measures. Our study aims to show the correlation between them in the first trimester itself, so that sufficient time is available to the doctor and the patient to take preventive measures to avoid perinatal and maternal morbidity. MATERIALS AND METHODS A prospective study was done in a tertiary care hospital during a period of 6 months. One hundred random pregnant women who came for booking visit were selected and Serum GGT was done. Later they were followed up with OGGT and diagnosed with GDM as per WHO criteria. RESULTS In our study, we found pregnant women in the age group of 30-40 years had higher incidence of GDM. The incidence rate of GDM in our study was 12%, which was high. Also, women with high BMI (Class 2 and Class 3) had higher incidence of GDM. A cut off of 30 U/L of Sr GGT was taken in our study. In our study of the 12 GDM patients, 10 had high Sr GGT. (83.3%) and 2 of them had normal values. Among non GDM women 2 had high Sr GGT values. A positive correlation with high GGT and GDM was done. GGT was found to be an independent risk factor for GDM especially with high FBS values. CONCLUSION GGT can be used as screening test for GDM.
Authors and Affiliations
Jyothi Prabhakar Rao, Rajini Jayakanthan V
Keywords
Related Articles
- EP ID EP611554
- DOI 10.18410/jebmh/2019/135
- Views 68
- Downloads 0
COMPARISON OF IMPROVEMENT IN CLINICAL, SPIROMETRIC AND OXYGENATION PARAMETERS AFTER NEBULISATION WITH LEVOSALBUTAMOL AND FORMOTEROLBUDESONIDE IN MODERATE TO SEVERE ASTHMA
BACKGROUND Asthma is characterized by recurrent attacks of breathlessness and wheezing, which vary in severity and frequency from person to person, 1 because asthma is a clinical syndrome, there is no gold standard for i...
EFFECT OF ISOMETRIC HAND GRIP EXERCISE TRAINING ON CARDIOVASCULAR AND ECHOCARDIOGRAPHIC PARAMETERS AMONG HEALTHY YOUNG MALES
Low level of physical fitness and sedentary life style is becoming one of the major risk factor of cardiovascular disease morbidity and mortality. Isometric hand grip exercise (IHG exercise) as a form of static resistanc...
DEXAMETHASONE-CYCLOPHOSPHAMIDE PULSE THERAPY IN PEMPHIGUS- A CLINICAL STUDY
BACKGROUND Pemphigus is an autoimmune bullous disorder which was life threatening before the advent of steroids and immunosuppressants. Dexamethasone Cyclophosphamide Pulse Therapy introduced by Pasricha and Gupta in 198...
A PROSPECTIVE, OBSERVATIONAL STUDY TO UNDERSTAND THE DRUG USAGE COMPOSITION OF ANTI-DIABETIC MEDICATIONS IN A RURAL CENTRE IN KERALA
BACKGROUND With exponentially higher number of patients being diagnosed with diabetes in India, it has gained an epidemic status here.1,2 Globally, the prevalence of diabetes in 2030 is expected to be almost double that...
ADULT VARIANT BARTTER’S SYNDROME- A CASE REPORT
BACKGROUND Bartter syndrome is a group of channelopathies with different genetic origins and molecular pathophysiologies, but sharing common feature of decreased tubular transport of sodium chloride in thick ascending lo...