Correlation between serum immunoglobulin levels and bronchial asthma
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 1
Abstract
Abstract: Immunoglobulins, also known as antibodies, are glycoprotein molecules produced by plasma cells (white blood cells). They act as a critical part of the immune response by specifically recognizing and binding to particular antigens. A hypersensitivity reaction initiated by immunologic mechanisms, mediated by IgE antibodies occurs in allergic asthma. The aim is to estimate and compare serum IgE levels in mild, moderate, and severe asthmatics and in normal subjects and to obtain a mathematical model describing the relationship between serum IgE levels and severity of asthma. A stratified sample of 50 patients within age group of 18-60 years and 34 male and 16 female asthmatic patients classified according to GINA classification. Serum IgE levels were estimated by using ELISA kit. Mean IgE in mild asthma patient was 444.4 IU/ml to 1002.3 IU/ml in severe asthmatics. Serum Immunoglobulin E levels were high in asthmatics and the value increase is dependent on severity of asthma. However, there was no statistically significant correlation since the variability in each level of asthma was very large. Keywords: Allergy, bronchial asthma, immunoglobulin E, inflammation
Authors and Affiliations
Vaibhav Krishna, Nitish Gupta, Dinesh Reddy
Keywords
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