“Correlation between Serum Prednisolone and Serum Albumin level in Childhood with Nephrotic Syndrome: A study in tertiary care hospital in Bangladesh”
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
Nephrotic syndrome, or nephrosis, is defined by the presence of nephrotic-range proteinuria, edema, hyperlipidemia, and hypoalbuminemia. While nephrotic-range proteinuria in adults is characterized by protein excretion of 3.5 g or more per day but in children it is defined as protein excretion of more than 40 mg/m2/h or a first-morning urine protein/ creatinine of 2-3 mg/mg creatinine or greater. Prednisolone is a steroid medication used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers, is very potent medication to treat children with nephrotic syndrome. The aim of this study was to evaluate the association between serum Prednisolone and serum albumin in childhood nephrotic syndrome. This prospective observational study was done in the department of Paediatric Nephrology &Kidney diseases, Dhaka Shishu (Children) Hospital, Sher - E - Bangla Nagar, Dhaka and Clinical Pharmacy & Pharmacology Dept. University of Dhaka from January 2014 to December 2014. Serum Prednisolone and serum Albumin were measured by enzymatic colorimetric method. The relationship between serum Prednisolone and serum Albumin was shown by Chi-square test and Paired‘t’ test. Serum prednisolone was measured in nephrotic syndrome during active phase & in remission and the average values were 2.088795 mic. mol/ml& 2.175277 mic.mol/ml respectively which was significantly high in remission of NS. This was not done previously in our country. Serum albumin was also measured in this study, average s. albumin level during active phase & in remission were 9.339318 gm/L & 20.4907 gm/L respectively which was significantly high in remission of NS.
Authors and Affiliations
Abu Bakkir Siddique, Mohammed Hanif, Farid Ahmed, Nazia Hossain, Maizbha Uddin
Keywords
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