Correlation between Serum Prostate Specific Antigen levels with Incidence of Bone Metastases in Newly Diagnosed Prostate Cancer Patients in Indian Population
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 3
Abstract
Introduction: Prostate cancer is second most frequently diagnosed cancer of men and bone is the commonest site of metastasis in them. There is lack of consensus for the selection criteria for bone scan in low risk patients. Western guidelines do not recommend use of bone scan in asymptomatic patients and in low PSA values. We try to correlate the PSA value with bone metastases through bone scan in Indian population. Material and Methods: 89 males of histologically proven carcinoma prostate over the period of 15 months, from March 2014 to May 2015 were included in the study. The patients were stratified into 3 groups according to their PSA level: the first group of patients had PSA level ranging from 0 - 10 ng/ml (n = 32), the second group had PSA level ranging from 10.1 - 20 ng/ml (n= 9), the third group had PSA levels > 20 ng/ml (n = 48). Results: The incidence of osseous metastases proven by bone scintigraphy was found to be 25% (8 out of 32) for PSA level 0 - 10 ng/ml, to 22.2 % (2 out of 9) for PSA level 10.1-20 and 68.7% (33 out of 48) for PSA level > 20 ng/ml (P < 0.001). The incidence of bone metastases < 20ng/ml is 21.73 % (10/46) (table-3). All patients (n=17) with PSA value>100 ng/ml were having bone metastases. Conclusion: The correlation between PSA value and both presence and metastases confirms the usefulness of bone scan scintigraphy in prostate cancer staging. Bone scan should be part of initial evaluation in all patients irrespective of serum PSA value as even patients with PSA values< 20 ng/ml are presenting with bone metastases.There should not be any minimal threshold limit of PSA for referring patients to bone scan.
Authors and Affiliations
Amit Sharma
Keywords
Related Articles
- EP ID EP277358
- DOI -
- Views 48
- Downloads 0
Uncommon Presentation of Snake Bite
A 26 years male patient was presented to us two days after snakebite on forehead. Few hours subsequently to bite he developed neuromuscular weakness with difficulty in breathing requiring mechanical ventilatory support....
Melanotic Neuroectodermal Tumor of Infancy: A Rare Case Report
Abstract
Reference Values of Ocular Dimensions in Emmetropic Children in South West Nigeria
Background: Ocular dimensions are important in determining the refractive status of the eye. Aim: To determine the reference values for ocular axial dimensions including anterior chamber depth (ACD), lens thickness (LT),...
A Study on the Effectiveness of a Structured Information Booklet on Patients & Caregivers Knowledge, Attitude and Practice Regarding Prevention of Complications Due to Immobilisation
Introduction: Immobilization is a most common treatment provided to injured patients admitted to the orthopedic . Immobilized patients have the highest risk of complications and death associated with it. Objective: 1.To...
To Study the Effectiveness of Para cervical Block in Accelerating Active Phase of Labour
The objective of the study was to ascertain the effectiveness of paracervical block in acceleration of active stage of labour in antenatal mothers (1) and to compare the results with controls, its effects on the fetus wa...